Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexam...
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Format: | Article |
Language: | English |
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Elsevier
2023-07-01
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Series: | Heliyon |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023048296 |
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author | Yongqing Ye Jin Xu Yuhan Han |
author_facet | Yongqing Ye Jin Xu Yuhan Han |
author_sort | Yongqing Ye |
collection | DOAJ |
description | The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexamethasone to routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier by directly increasing the expression of ZO-1, and reduce the neuroinflammatory response caused by NF-κB pathway by upregulating KLF2 expression, ultimately reducing nerve injury through multiple pathways. |
first_indexed | 2024-03-12T21:38:17Z |
format | Article |
id | doaj.art-3d4a7eb17e584d70a27d03b8cc447e57 |
institution | Directory Open Access Journal |
issn | 2405-8440 |
language | English |
last_indexed | 2024-03-12T21:38:17Z |
publishDate | 2023-07-01 |
publisher | Elsevier |
record_format | Article |
series | Heliyon |
spelling | doaj.art-3d4a7eb17e584d70a27d03b8cc447e572023-07-27T05:56:51ZengElsevierHeliyon2405-84402023-07-0197e17621Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?Yongqing Ye0Jin Xu1Yuhan Han2Department of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150000, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Corresponding author. Department of Neurosurgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China.Department of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Corresponding author. Department of Neurosurgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China.The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexamethasone to routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier by directly increasing the expression of ZO-1, and reduce the neuroinflammatory response caused by NF-κB pathway by upregulating KLF2 expression, ultimately reducing nerve injury through multiple pathways.http://www.sciencedirect.com/science/article/pii/S2405844023048296Delayed cerebral edemaDexamethasoneBlood-brain barrierNeuroinflammatoryKLF2 |
spellingShingle | Yongqing Ye Jin Xu Yuhan Han Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? Heliyon Delayed cerebral edema Dexamethasone Blood-brain barrier Neuroinflammatory KLF2 |
title | Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? |
title_full | Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? |
title_fullStr | Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? |
title_full_unstemmed | Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? |
title_short | Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be? |
title_sort | dexamethasone for delayed edema after intracerebral hemorrhage to be or not to be |
topic | Delayed cerebral edema Dexamethasone Blood-brain barrier Neuroinflammatory KLF2 |
url | http://www.sciencedirect.com/science/article/pii/S2405844023048296 |
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