Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?

The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexam...

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Main Authors: Yongqing Ye, Jin Xu, Yuhan Han
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023048296
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author Yongqing Ye
Jin Xu
Yuhan Han
author_facet Yongqing Ye
Jin Xu
Yuhan Han
author_sort Yongqing Ye
collection DOAJ
description The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexamethasone to routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier by directly increasing the expression of ZO-1, and reduce the neuroinflammatory response caused by NF-κB pathway by upregulating KLF2 expression, ultimately reducing nerve injury through multiple pathways.
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spelling doaj.art-3d4a7eb17e584d70a27d03b8cc447e572023-07-27T05:56:51ZengElsevierHeliyon2405-84402023-07-0197e17621Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?Yongqing Ye0Jin Xu1Yuhan Han2Department of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150000, ChinaDepartment of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Corresponding author. Department of Neurosurgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China.Department of Neurosurgery, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China; Corresponding author. Department of Neurosurgery, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, Suqian 223800, China.The pathogenesis of delayed cerebral edema after intracerebral hemorrhage is still unclear. In this case report, we speculate that the formation of subdural effusion or hemorrhage is associated with delayed cerebral edema. By referring to the treatment plan of chronic subdural hematoma, adding dexamethasone to routine medication, certain therapeutic effect has been achieved. Dexamethasone may maintain the stability of blood-brain barrier by directly increasing the expression of ZO-1, and reduce the neuroinflammatory response caused by NF-κB pathway by upregulating KLF2 expression, ultimately reducing nerve injury through multiple pathways.http://www.sciencedirect.com/science/article/pii/S2405844023048296Delayed cerebral edemaDexamethasoneBlood-brain barrierNeuroinflammatoryKLF2
spellingShingle Yongqing Ye
Jin Xu
Yuhan Han
Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
Heliyon
Delayed cerebral edema
Dexamethasone
Blood-brain barrier
Neuroinflammatory
KLF2
title Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
title_full Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
title_fullStr Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
title_full_unstemmed Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
title_short Dexamethasone for delayed edema after intracerebral hemorrhage: To be or not to be?
title_sort dexamethasone for delayed edema after intracerebral hemorrhage to be or not to be
topic Delayed cerebral edema
Dexamethasone
Blood-brain barrier
Neuroinflammatory
KLF2
url http://www.sciencedirect.com/science/article/pii/S2405844023048296
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AT jinxu dexamethasonefordelayededemaafterintracerebralhemorrhagetobeornottobe
AT yuhanhan dexamethasonefordelayededemaafterintracerebralhemorrhagetobeornottobe