GeTallele: A Method for Analysis of DNA and RNA Allele Frequency Distributions

GeTallele: A Method for Analysis of DNA and RNA Allele Frequency Distributions

Variant allele frequencies (VAF) are an important measure of genetic variation that can be estimated at single-nucleotide variant (SNV) sites. RNA and DNA VAFs are used as indicators of a wide-range of biological traits, including tumor purity and ploidy changes, allele-specific expression and gene-...

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Bibliographic Details
Main Authors: Piotr Słowiński, Muzi Li, Paula Restrepo, Nawaf Alomran, Liam F. Spurr, Christian Miller, Krasimira Tsaneva-Atanasova, Anelia Horvath
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
variant allele fraction (VAF)
RNA—DNA
earth mover's distance (EMD)
circos plot
farey sequence
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.01021/full

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