Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor
A functional activity of erythroid hematopoietic cells of patients with chronic myeloid leukemia, who were treated with tyrosine kinase inhibitor of the first and second generation was investigated. Samples of bone marrow of patients with resistance to tyrosine kinase inhibitor treatment show an inc...
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2016-07-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
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| Online Access: | http://biovestnik.com/index.php/biology/article/view/30 |
| _version_ | 1797715836502278144 |
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| author | I. Sviezhentseva D. Bilko N. Bilko I. Dyagil |
| author_facet | I. Sviezhentseva D. Bilko N. Bilko I. Dyagil |
| author_sort | I. Sviezhentseva |
| collection | DOAJ |
| description | A functional activity of erythroid hematopoietic cells of patients with chronic myeloid leukemia, who were treated with tyrosine kinase inhibitor of the first and second generation was investigated. Samples of bone marrow of patients with resistance to tyrosine kinase inhibitor treatment show an increase of erythroid colonies number provided that there is erythropoietin in the culture medium. Furthermore, it was found that clone cells in culture in vitro acquire the ability to differentiate towards erythroid direction in the absence of a culture medium culturing exogenous erythropoietin when they have a resistance to imatinib and nilotinib. Thus, the determination of proliferative activity of erythroid hematopoiesis level in cultured cells in vitro may serve as an important prognostic factor for the further choice of treatment strategy. |
| first_indexed | 2024-03-12T08:12:40Z |
| format | Article |
| id | doaj.art-3d4d5e81efa748c3acde2599828c94d4 |
| institution | Directory Open Access Journal |
| issn | 1728-2748 2308-8036 |
| language | English |
| last_indexed | 2024-03-12T08:12:40Z |
| publishDate | 2016-07-01 |
| publisher | Taras Shevchenko National University of Kyiv |
| record_format | Article |
| series | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| spelling | doaj.art-3d4d5e81efa748c3acde2599828c94d42023-09-02T19:06:26ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362016-07-01683515410.17721/1728_2748.2014.68.51-5430Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitorI. Sviezhentseva0D. Bilko1N. Bilko2I. Dyagil3National University of "Kyiv-Mohyla Academy", KyivNational University of "Kyiv-Mohyla Academy", KyivNational University of "Kyiv-Mohyla Academy", KyivND "Scientific Center for Radiation Medicine, Academy of Medical Sciences of Ukraine", KyivA functional activity of erythroid hematopoietic cells of patients with chronic myeloid leukemia, who were treated with tyrosine kinase inhibitor of the first and second generation was investigated. Samples of bone marrow of patients with resistance to tyrosine kinase inhibitor treatment show an increase of erythroid colonies number provided that there is erythropoietin in the culture medium. Furthermore, it was found that clone cells in culture in vitro acquire the ability to differentiate towards erythroid direction in the absence of a culture medium culturing exogenous erythropoietin when they have a resistance to imatinib and nilotinib. Thus, the determination of proliferative activity of erythroid hematopoiesis level in cultured cells in vitro may serve as an important prognostic factor for the further choice of treatment strategy.http://biovestnik.com/index.php/biology/article/view/30chronic myeloid leukemia, tyrosine kinase inhibitors, erythropoiesis, cell culture in vitro |
| spellingShingle | I. Sviezhentseva D. Bilko N. Bilko I. Dyagil Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ chronic myeloid leukemia, tyrosine kinase inhibitors, erythropoiesis, cell culture in vitro |
| title | Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| title_full | Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| title_fullStr | Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| title_full_unstemmed | Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| title_short | Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| title_sort | features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor |
| topic | chronic myeloid leukemia, tyrosine kinase inhibitors, erythropoiesis, cell culture in vitro |
| url | http://biovestnik.com/index.php/biology/article/view/30 |
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