Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway

Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway

ObjectiveTacrolimus (Tac) is an immunosuppressant used in the treatment of systemic lupus erythematosus (SLE); however, it induces T cell subset imbalances by reducing regulatory T (Treg) cells. Lactobacillus acidophilus (LA) is reported to have therapeutic efficacy in immune-mediated diseases via T...

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Bibliographic Details
Main Authors: Da Som Kim, Youngjae Park, Jeong-Won Choi, Sung-Hwan Park, Mi-La Cho, Seung-Ki Kwok
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
gut microbiome
Tacrolimus
Lactobacillus acidophilus
T helper 17 cell
regulatory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.696074/full

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