Porcine Macrophage Markers and Populations: An Update
Besides its importance as a livestock species, pig is increasingly being used as an animal model for biomedical research. Macrophages play critical roles in immunity to pathogens, tissue development, homeostasis and tissue repair. These cells are also primary targets for replication of viruses such...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/12/16/2103 |
| _version_ | 1797585170049531904 |
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| author | Belén Álvarez Concepción Revilla Teresa Poderoso Angel Ezquerra Javier Domínguez |
| author_facet | Belén Álvarez Concepción Revilla Teresa Poderoso Angel Ezquerra Javier Domínguez |
| author_sort | Belén Álvarez |
| collection | DOAJ |
| description | Besides its importance as a livestock species, pig is increasingly being used as an animal model for biomedical research. Macrophages play critical roles in immunity to pathogens, tissue development, homeostasis and tissue repair. These cells are also primary targets for replication of viruses such as African swine fever virus, classical swine fever virus, and porcine respiratory and reproductive syndrome virus, which can cause huge economic losses to the pig industry. In this article, we review the current status of knowledge on porcine macrophages, starting by reviewing the markers available for their phenotypical characterization and following with the characteristics of the main macrophage populations described in different organs, as well as the effect of polarization conditions on their phenotype and function. We will also review available cell lines suitable for studies on the biology of porcine macrophages and their interaction with pathogens. |
| first_indexed | 2024-03-11T00:02:05Z |
| format | Article |
| id | doaj.art-3d4e9db4ad46439583dae378df470560 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T00:02:05Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3d4e9db4ad46439583dae378df4705602023-11-19T00:37:34ZengMDPI AGCells2073-44092023-08-011216210310.3390/cells12162103Porcine Macrophage Markers and Populations: An UpdateBelén Álvarez0Concepción Revilla1Teresa Poderoso2Angel Ezquerra3Javier Domínguez4Departamento de Biotecnología, CSIC INIA, Ctra. De La Coruña, km7.5, 28040 Madrid, SpainDepartamento de Biotecnología, CSIC INIA, Ctra. De La Coruña, km7.5, 28040 Madrid, SpainDepartamento de Biotecnología, CSIC INIA, Ctra. De La Coruña, km7.5, 28040 Madrid, SpainDepartamento de Biotecnología, CSIC INIA, Ctra. De La Coruña, km7.5, 28040 Madrid, SpainDepartamento de Biotecnología, CSIC INIA, Ctra. De La Coruña, km7.5, 28040 Madrid, SpainBesides its importance as a livestock species, pig is increasingly being used as an animal model for biomedical research. Macrophages play critical roles in immunity to pathogens, tissue development, homeostasis and tissue repair. These cells are also primary targets for replication of viruses such as African swine fever virus, classical swine fever virus, and porcine respiratory and reproductive syndrome virus, which can cause huge economic losses to the pig industry. In this article, we review the current status of knowledge on porcine macrophages, starting by reviewing the markers available for their phenotypical characterization and following with the characteristics of the main macrophage populations described in different organs, as well as the effect of polarization conditions on their phenotype and function. We will also review available cell lines suitable for studies on the biology of porcine macrophages and their interaction with pathogens.https://www.mdpi.com/2073-4409/12/16/2103swinemacrophagesurface markersphenotypesubsets |
| spellingShingle | Belén Álvarez Concepción Revilla Teresa Poderoso Angel Ezquerra Javier Domínguez Porcine Macrophage Markers and Populations: An Update Cells swine macrophage surface markers phenotype subsets |
| title | Porcine Macrophage Markers and Populations: An Update |
| title_full | Porcine Macrophage Markers and Populations: An Update |
| title_fullStr | Porcine Macrophage Markers and Populations: An Update |
| title_full_unstemmed | Porcine Macrophage Markers and Populations: An Update |
| title_short | Porcine Macrophage Markers and Populations: An Update |
| title_sort | porcine macrophage markers and populations an update |
| topic | swine macrophage surface markers phenotype subsets |
| url | https://www.mdpi.com/2073-4409/12/16/2103 |
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