Ivalin Induces Mitochondria-Mediated Apoptosis Associated with the NF-κB Activation in Human Hepatocellular Carcinoma SMMC-7721 Cells

Ivalin Induces Mitochondria-Mediated Apoptosis Associated with the NF-κB Activation in Human Hepatocellular Carcinoma SMMC-7721 Cells

Ivalin, a natural compound isolated from <i>Carpesium divaricatum</i>, showed excellent microtubule depolymerization activities among human hepatocellular carcinoma in our previous work. Here, we investigated its functions on mitochondria-mediated apoptosis in hepatocellular carcinoma SM...

Full description

Bibliographic Details
Main Authors:	Zhuo Han, Fang-yuan Liu, Shi-qi Lin, Cai-yun Zhang, Jia-hui Ma, Chao Guo, Fu-juan Jia, Qian Zhang, Wei-dong Xie, Xia Li
Format:	Article
Language:	English
Published:	MDPI AG 2019-10-01
Series:	Molecules
Subjects:	ivalin <i>carpesium divaricatum</i> hepatocellular carcinoma mitochondria-mediated apoptosis nf-κb
Online Access:	https://www.mdpi.com/1420-3049/24/20/3809

Similar Items

The Novel Nature Microtubule Inhibitor Ivalin Induces G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells In Vitro
by: Fangyuan Liu, et al.
Published: (2019-08-01)

Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity
by: Tao Zhang, et al.
Published: (2018-05-01)

New 11-Methoxymethylgermacranolides from the Whole Plant of <i>Carpesium divaricatum</i>
by: Tao Zhang, et al.
Published: (2022-09-01)

<i>Carpesium divaricatum</i> Sieb. & Zucc. Revisited: Newly Identified Constituents from Aerial Parts of the Plant and Their Possible Contribution to the Biological Activity of the Plant
by: Natalia Kłeczek, et al.
Published: (2019-04-01)

Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma
by: Po Yee Chung, et al.
Published: (2018-10-01)

NF-κB and Its Regulators During Pregnancy
by: Fernando Gómez-Chávez, et al.
Published: (2021-05-01)

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition
by: Weiping Zhu, et al.
Published: (2016-11-01)

At the crossroads of SUMO and NF-κB
by: Schmidt Christian, et al.
Published: (2003-11-01)

Chemical composition, circadian rhythm and antibacterial activity of essential oils of piper divaricatum: a new source of safrole
by: Queila P. S. Barbosa, et al.
Published: (2012-01-01)

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells
by: Chakrabhavi Dhananjaya Mohan, et al.
Published: (2018-03-01)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
by: Carlota Colomer, et al.
Published: (2017-05-01)

Anti-Migration Effects of Gekko Sulfated Glycopeptide on Human Hepatoma SMMC-7721 Cells
by: Xiong-Zhi Wu, et al.
Published: (2011-06-01)

CSNK2A2 promotes hepatocellular carcinoma progression through activation of NF-κB pathway
by: Shuang Yang, et al.
Published: (2023-09-01)

Anthocyanins Derived from <i>Vitis coignetiae Pulliat</i> Contributes Anti-Cancer Effects by Suppressing NF-κB Pathways in Hep3B Human Hepatocellular Carcinoma Cells and In Vivo
by: Min Jeong Kim, et al.
Published: (2020-11-01)

Recombinant VAA-I from Viscum album Induces Apoptotic Cell Death of Hepatocellular Carcinoma SMMC7721 Cells
by: Shuli Xie, et al.
Published: (2012-09-01)

FER Regulated by miR-206 Promotes Hepatocellular Carcinoma Progression via NF-κB Signaling
by: Wenzhou Ding, et al.
Published: (2021-07-01)

The Therapeutic Role of PNU-74654 in Hepatocellular Carcinoma May Involve Suppression of NF-κB Signaling
by: Min-You Wu, et al.
Published: (2022-06-01)

Silencing of TRAF5 enhances necroptosis in hepatocellular carcinoma by inhibiting LTBR-mediated NF-κB signaling
by: Guolin Wu, et al.
Published: (2023-06-01)

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression
by: Polly Downton, et al.
Published: (2023-05-01)

Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway
by: Lin Hou, et al.
Published: (2013-06-01)

Composition of Lycium barbarum polysaccharides and their apoptosis-inducing effect on human hepatoma SMMC-7721 cells
by: Qian Zhang, et al.
Published: (2015-11-01)

Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
by: Chen Baoan, et al.
Published: (2009-01-01)

Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target
by: Xuan Xu, et al.
Published: (2021-08-01)

Germacranolides from <i>Carpesium divaricatum</i>: Some New Data on Cytotoxic and Anti-Inflammatory Activity
by: Natalia Kłeczek, et al.
Published: (2021-07-01)

Bis-benzylidine Piperidone RA190 treatment of hepatocellular carcinoma via binding RPN13 and inhibiting NF-κB signaling
by: Ruey-Shyang Soong, et al.
Published: (2020-05-01)

ZBTB20 promotes cell migration and invasion of gastric cancer by inhibiting IκBα to induce NF-κB activation
by: Yangmei Zhang, et al.
Published: (2019-12-01)

Atypical IκB Bcl3 enhances the generation of the NF-κB p52 homodimer
by: Wenfei Pan, et al.
Published: (2022-08-01)

Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
by: Zhang Y, et al.
Published: (2019-04-01)

Reduced IκB-α Protein Levels in Peripheral Blood Cells of Patients with Multiple Sclerosis—A Possible Cause of Constitutive NF-κB Activation
by: Jun Yan, et al.
Published: (2020-08-01)

Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT
by: Wei Y, et al.
Published: (2019-07-01)

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism
by: Liyao Deng, et al.
Published: (2018-08-01)

Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
by: Qing Yang, et al.
Published: (2019-06-01)

Rosmarinic acid inhibits inflammation and angiogenesis of hepatocellular carcinoma by suppression of NF-κB signaling in H22 tumor-bearing mice
by: Wen Cao, et al.
Published: (2016-10-01)

Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia
by: Bambanani Zozo, et al.
Published: (2021-01-01)

Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of <i>Cassia obtusifolia</i> L. through Modulation of the NF-κB Pathway
by: Jingyi Hou, et al.
Published: (2018-11-01)

Review: NF-κB pathways in the pathogenesis of Multiple Sclerosis and the therapeutic implications
by: Saskia Michaela Leibowitz, et al.
Published: (2016-09-01)

Effect of Down-regulation of MLLT3/AF9 Expression on Proliferation and Invasion Abilities of Hepatoma SMMC-7721 Cells
by: FENG Pengcheng, et al.
Published: (2018-05-01)

NF-κB in Hematological Malignancies
by: Véronique Imbert, et al.
Published: (2017-05-01)

Ginsenoside CK Inhibits Hypoxia-Induced Epithelial–Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma
by: Jingjing Zhang, et al.
Published: (2021-05-01)

Role of NF-κB during <i>Mycobacterium tuberculosis</i> Infection
by: Nicole Poladian, et al.
Published: (2023-01-01)