Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study
AbstractUsing Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichmen...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | The Aging Male |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2023.2261524 |
| _version_ | 1797434753982398464 |
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| author | Xiwen Liu Lixuan Lin Qi Cai Caichen Li Haoxiang Xu Ruiqi Zeng Mingtong Zhang Xinyi Qiu Shiqi Chen Xizhe Zhang Linchong Huang Wenhua Liang Jianxing He |
| author_facet | Xiwen Liu Lixuan Lin Qi Cai Caichen Li Haoxiang Xu Ruiqi Zeng Mingtong Zhang Xinyi Qiu Shiqi Chen Xizhe Zhang Linchong Huang Wenhua Liang Jianxing He |
| author_sort | Xiwen Liu |
| collection | DOAJ |
| description | AbstractUsing Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers. |
| first_indexed | 2024-03-09T10:37:34Z |
| format | Article |
| id | doaj.art-3d507e6da8a74e579239d20dcd7d23f2 |
| institution | Directory Open Access Journal |
| issn | 1368-5538 1473-0790 |
| language | English |
| last_indexed | 2024-03-09T10:37:34Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Aging Male |
| spelling | doaj.art-3d507e6da8a74e579239d20dcd7d23f22023-12-01T20:52:03ZengTaylor & Francis GroupThe Aging Male1368-55381473-07902023-12-0126110.1080/13685538.2023.2261524Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics studyXiwen Liu0Lixuan Lin1Qi Cai2Caichen Li3Haoxiang Xu4Ruiqi Zeng5Mingtong Zhang6Xinyi Qiu7Shiqi Chen8Xizhe Zhang9Linchong Huang10Wenhua Liang11Jianxing He12Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaThe Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaFirst Clinical School, Guangzhou Medical University, Guangzhou, ChinaFirst Clinical School, Guangzhou Medical University, Guangzhou, ChinaFirst Clinical School, Guangzhou Medical University, Guangzhou, ChinaFirst Clinical School, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaDepartment of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, ChinaAbstractUsing Mendelian Randomization (MR) and large-scale Genome-Wide Association Study (GWAS) data, this study aimed to investigate the potential causative relationship between testosterone and sex hormone-binding globulin (SHBG) levels and the onset of several cancers, including pathway enrichment analyses of single nucleotide polymorphisms (SNPs) associated with cancer allowed for a comprehensive bioinformatics approach, which offered a deeper biological understanding of these relationships. The results indicated that increased testosterone levels in women were associated with a higher risk of breast and cervical cancers but a lower risk of ovarian cancer. Conversely, increased testosterone was linked to lower stomach cancer risk for men, whereas high SHBG levels were related to decreased risks of breast and prostate cancers. The corresponding genes of the identified SNPs, as revealed by pathway enrichment analysis, were involved in significant metabolic and proliferative pathways. These findings emphasize the need for further research into the biological mechanisms behind these associations, paving the way for potential targeted interventions in preventing and treating these cancers.https://www.tandfonline.com/doi/10.1080/13685538.2023.2261524Sex hormone binding globulintestosteronecancermendelian randomizationbioinformatical analysis |
| spellingShingle | Xiwen Liu Lixuan Lin Qi Cai Caichen Li Haoxiang Xu Ruiqi Zeng Mingtong Zhang Xinyi Qiu Shiqi Chen Xizhe Zhang Linchong Huang Wenhua Liang Jianxing He Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study The Aging Male Sex hormone binding globulin testosterone cancer mendelian randomization bioinformatical analysis |
| title | Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study |
| title_full | Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study |
| title_fullStr | Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study |
| title_full_unstemmed | Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study |
| title_short | Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study |
| title_sort | do testosterone and sex hormone binding globulin affect cancer risk a mendelian randomization and bioinformatics study |
| topic | Sex hormone binding globulin testosterone cancer mendelian randomization bioinformatical analysis |
| url | https://www.tandfonline.com/doi/10.1080/13685538.2023.2261524 |
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