Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
Summary: Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure. Using recently curated single-cell RNASeq data from T1D or T2D donors and their controls, we identified alpha cell transcriptomic alterations...
Main Authors: | Emanuele Bosi, Piero Marchetti, Guy Allen Rutter, Decio Laks Eizirik |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-10-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222013281 |
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