A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration
Unlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for ma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/1/35 |
| _version_ | 1797495513656852480 |
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| author | Zulvikar Syambani Ulhaq William Ka Fai Tse |
| author_facet | Zulvikar Syambani Ulhaq William Ka Fai Tse |
| author_sort | Zulvikar Syambani Ulhaq |
| collection | DOAJ |
| description | Unlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for mammals (including humans). Hence, we systematically analyzed the current literature on the proteome profile collected from different regenerated zebrafish tissues. Our analyses underlining that several proteins and protein families responsible as a component of cytoskeleton and structure, protein synthesis and degradation, cell cycle control, and energy metabolism were frequently identified. Moreover, target proteins responsible for the initiation of the regeneration process, such as inflammation and immune response were less frequently detected. This highlights the limitation of previous proteomic analysis and suggested a more sensitive modern proteomics analysis is needed to unfold the mechanism. This brief report provides a list of target proteins with predicted functions that could be useful for further biological studies. |
| first_indexed | 2024-03-10T01:50:50Z |
| format | Article |
| id | doaj.art-3d51feecf30d485989e84423d121a3b7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T01:50:50Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3d51feecf30d485989e84423d121a3b72023-11-23T13:05:59ZengMDPI AGBiomolecules2218-273X2021-12-011213510.3390/biom12010035A Brief Analysis of Proteomic Profile Changes during Zebrafish RegenerationZulvikar Syambani Ulhaq0William Ka Fai Tse1Department of Biochemistry, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University of Malang, Batu 65144, IndonesiaLaboratory of Developmental Disorders and Toxicology, Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, JapanUnlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for mammals (including humans). Hence, we systematically analyzed the current literature on the proteome profile collected from different regenerated zebrafish tissues. Our analyses underlining that several proteins and protein families responsible as a component of cytoskeleton and structure, protein synthesis and degradation, cell cycle control, and energy metabolism were frequently identified. Moreover, target proteins responsible for the initiation of the regeneration process, such as inflammation and immune response were less frequently detected. This highlights the limitation of previous proteomic analysis and suggested a more sensitive modern proteomics analysis is needed to unfold the mechanism. This brief report provides a list of target proteins with predicted functions that could be useful for further biological studies.https://www.mdpi.com/2218-273X/12/1/35proteomicregenerationcaudal finheartreparative neurogenesiszebrafish |
| spellingShingle | Zulvikar Syambani Ulhaq William Ka Fai Tse A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration Biomolecules proteomic regeneration caudal fin heart reparative neurogenesis zebrafish |
| title | A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration |
| title_full | A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration |
| title_fullStr | A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration |
| title_full_unstemmed | A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration |
| title_short | A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration |
| title_sort | brief analysis of proteomic profile changes during zebrafish regeneration |
| topic | proteomic regeneration caudal fin heart reparative neurogenesis zebrafish |
| url | https://www.mdpi.com/2218-273X/12/1/35 |
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