Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

<p>Abstract</p> <p>Background</p> <p>Chemotherapy resistance remains a major obstacle for the treatment of small cell lung cancer (SCLC). Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, plays a critical role in chemotherapy resistance in some c...

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Bibliographic Details
Main Authors: Shao Shujuan, Wang Jiarui, Wang Siyan, Wang Wei, Wang Yingyan, Wang Qi
Format: Article
Language:English
Published: BMC 2008-12-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/372

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