Association of cardiometabolic risk factors with insulin resistance in overweight and obese children
Abstract Introduction Regarding the increased prevalence of obesity among children and adolescents, and the impact of obesity on insulin resistance (IR) and other metabolic disorders, this study was performed to determine the association of cardiometabolic risk factors (CMRFs) with IR in overweight...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-022-01245-7 |
| _version_ | 1797977393627922432 |
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| author | Elnaz Daneshzad Sayeh Rostami Fatemeh Aghamahdi Armita Mahdavi-Gorabi Mostafa Qorbani |
| author_facet | Elnaz Daneshzad Sayeh Rostami Fatemeh Aghamahdi Armita Mahdavi-Gorabi Mostafa Qorbani |
| author_sort | Elnaz Daneshzad |
| collection | DOAJ |
| description | Abstract Introduction Regarding the increased prevalence of obesity among children and adolescents, and the impact of obesity on insulin resistance (IR) and other metabolic disorders, this study was performed to determine the association of cardiometabolic risk factors (CMRFs) with IR in overweight and obese children. Method In this cross-sectional study 150 overweight and obese children (BMI ≥ 85th and BMI ≥ 95th age-sex specific percentile) and adolescents were selected via convenient sampling method from Endocrinology clinic in Karaj; Iran in 2020. Anthropometric indices, lipid profile, fasting blood glucose (FBG), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were evaluated. IR was defined as HOMA-IR ≥ 2.6. Multivariable linear and logistic regression model was used to assess the association of CMRFs with insulin level and IR respectively. Results The mean age of children was 10.37 (± 2.6) years. Fifty-four percent of the participants were girls. IR was increased through increasing age (P < 0.001). In the multivariate logistic regression model, by increasing each unit increment in waist circumference (OR: 1.03, 95% CI: 1.01–1.06), wrist circumference (OR: 1.47, 95% CI: 1.06–2.02) total cholesterol (OR: 1.01, 95% CI: 1.003–1.03) and FBG (OR: 1.11, 95% CI: 1.05–1.18) the odds of IR increased significantly. Moreover, in the adjusted linear regression model, HOMA-IR was associated significantly with waist to height ratio (β: 2.45), and FBG (β: 0.02). Conclusion There was a significant association between some CMRFS with IR in overweight and obese children. |
| first_indexed | 2024-04-11T05:06:11Z |
| format | Article |
| id | doaj.art-3d535ab2a5484876a58a1760f0dfb51d |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-11T05:06:11Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-3d535ab2a5484876a58a1760f0dfb51d2022-12-25T12:19:12ZengBMCBMC Endocrine Disorders1472-68232022-12-012211810.1186/s12902-022-01245-7Association of cardiometabolic risk factors with insulin resistance in overweight and obese childrenElnaz Daneshzad0Sayeh Rostami1Fatemeh Aghamahdi2Armita Mahdavi-Gorabi3Mostafa Qorbani4Non-Communicable Diseases Research Center, Alborz University of Medical SciencesStudent Research Committee, Alborz University of Medical SciencesDepartment of Pediatric Endocrinology, School of Medicine, Alborz University of Medical SciencesProbiotic Research Center, Alborz University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesAbstract Introduction Regarding the increased prevalence of obesity among children and adolescents, and the impact of obesity on insulin resistance (IR) and other metabolic disorders, this study was performed to determine the association of cardiometabolic risk factors (CMRFs) with IR in overweight and obese children. Method In this cross-sectional study 150 overweight and obese children (BMI ≥ 85th and BMI ≥ 95th age-sex specific percentile) and adolescents were selected via convenient sampling method from Endocrinology clinic in Karaj; Iran in 2020. Anthropometric indices, lipid profile, fasting blood glucose (FBG), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were evaluated. IR was defined as HOMA-IR ≥ 2.6. Multivariable linear and logistic regression model was used to assess the association of CMRFs with insulin level and IR respectively. Results The mean age of children was 10.37 (± 2.6) years. Fifty-four percent of the participants were girls. IR was increased through increasing age (P < 0.001). In the multivariate logistic regression model, by increasing each unit increment in waist circumference (OR: 1.03, 95% CI: 1.01–1.06), wrist circumference (OR: 1.47, 95% CI: 1.06–2.02) total cholesterol (OR: 1.01, 95% CI: 1.003–1.03) and FBG (OR: 1.11, 95% CI: 1.05–1.18) the odds of IR increased significantly. Moreover, in the adjusted linear regression model, HOMA-IR was associated significantly with waist to height ratio (β: 2.45), and FBG (β: 0.02). Conclusion There was a significant association between some CMRFS with IR in overweight and obese children.https://doi.org/10.1186/s12902-022-01245-7Cardiometabolic risk factorsInsulin resistanceOverweightObesityChild |
| spellingShingle | Elnaz Daneshzad Sayeh Rostami Fatemeh Aghamahdi Armita Mahdavi-Gorabi Mostafa Qorbani Association of cardiometabolic risk factors with insulin resistance in overweight and obese children BMC Endocrine Disorders Cardiometabolic risk factors Insulin resistance Overweight Obesity Child |
| title | Association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| title_full | Association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| title_fullStr | Association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| title_full_unstemmed | Association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| title_short | Association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| title_sort | association of cardiometabolic risk factors with insulin resistance in overweight and obese children |
| topic | Cardiometabolic risk factors Insulin resistance Overweight Obesity Child |
| url | https://doi.org/10.1186/s12902-022-01245-7 |
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