Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity
The emergence and the dissemination of multidrug-resistant bacteria constitute a major public health issue. Among incriminated Gram-negative bacteria, <i>Pseudomonas aeruginosa</i> has been designated by the WHO as a critical priority threat. During the infection process, this pathogen s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1262 |
| _version_ | 1797501564244459520 |
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| author | Marine Duplantier Elodie Lohou Pascal Sonnet |
| author_facet | Marine Duplantier Elodie Lohou Pascal Sonnet |
| author_sort | Marine Duplantier |
| collection | DOAJ |
| description | The emergence and the dissemination of multidrug-resistant bacteria constitute a major public health issue. Among incriminated Gram-negative bacteria, <i>Pseudomonas aeruginosa</i> has been designated by the WHO as a critical priority threat. During the infection process, this pathogen secretes various virulence factors in order to adhere and colonize host tissues. Furthermore, <i>P. aeruginosa</i> has the capacity to establish biofilms that reinforce its virulence and intrinsic drug resistance. The regulation of biofilm and virulence factor production of this micro-organism is controlled by a specific bacterial communication system named Quorum Sensing (QS). The development of anti-virulence agents targeting QS that could attenuate <i>P. aeruginosa</i> pathogenicity without affecting its growth seems to be a promising new therapeutic strategy. This could prevent the selective pressure put on bacteria by the conventional antibiotics that cause their death and promote resistant strain survival. This review describes the QS-controlled pathogenicity of <i>P. aeruginosa</i> and its different specific QS molecular pathways, as well as the recent advances in the development of innovative QS-quenching anti-virulence agents to fight anti-bioresistance. |
| first_indexed | 2024-03-10T03:20:15Z |
| format | Article |
| id | doaj.art-3d55ec37b5ce484ea39b8ae951e294ec |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:20:15Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-3d55ec37b5ce484ea39b8ae951e294ec2023-11-23T10:03:18ZengMDPI AGPharmaceuticals1424-82472021-12-011412126210.3390/ph14121262Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> PathogenicityMarine Duplantier0Elodie Lohou1Pascal Sonnet2AGIR, UR4294, UFR of Pharmacy, Jules Verne University of Picardie, 80037 Amiens, FranceAGIR, UR4294, UFR of Pharmacy, Jules Verne University of Picardie, 80037 Amiens, FranceAGIR, UR4294, UFR of Pharmacy, Jules Verne University of Picardie, 80037 Amiens, FranceThe emergence and the dissemination of multidrug-resistant bacteria constitute a major public health issue. Among incriminated Gram-negative bacteria, <i>Pseudomonas aeruginosa</i> has been designated by the WHO as a critical priority threat. During the infection process, this pathogen secretes various virulence factors in order to adhere and colonize host tissues. Furthermore, <i>P. aeruginosa</i> has the capacity to establish biofilms that reinforce its virulence and intrinsic drug resistance. The regulation of biofilm and virulence factor production of this micro-organism is controlled by a specific bacterial communication system named Quorum Sensing (QS). The development of anti-virulence agents targeting QS that could attenuate <i>P. aeruginosa</i> pathogenicity without affecting its growth seems to be a promising new therapeutic strategy. This could prevent the selective pressure put on bacteria by the conventional antibiotics that cause their death and promote resistant strain survival. This review describes the QS-controlled pathogenicity of <i>P. aeruginosa</i> and its different specific QS molecular pathways, as well as the recent advances in the development of innovative QS-quenching anti-virulence agents to fight anti-bioresistance.https://www.mdpi.com/1424-8247/14/12/1262anti-bioresistance<i>Pseudomonas aeruginosa</i>biofilmsvirulence factorsanti-virulence strategybacterial communication systems |
| spellingShingle | Marine Duplantier Elodie Lohou Pascal Sonnet Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity Pharmaceuticals anti-bioresistance <i>Pseudomonas aeruginosa</i> biofilms virulence factors anti-virulence strategy bacterial communication systems |
| title | Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity |
| title_full | Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity |
| title_fullStr | Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity |
| title_full_unstemmed | Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity |
| title_short | Quorum Sensing Inhibitors to Quench <i>P. aeruginosa</i> Pathogenicity |
| title_sort | quorum sensing inhibitors to quench i p aeruginosa i pathogenicity |
| topic | anti-bioresistance <i>Pseudomonas aeruginosa</i> biofilms virulence factors anti-virulence strategy bacterial communication systems |
| url | https://www.mdpi.com/1424-8247/14/12/1262 |
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