Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment
The objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the carboxylic functional groups coating magnetic nanoparti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2016.1256001 |
| _version_ | 1819177197208862720 |
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| author | Xin Hua Qin Yang Zhimin Dong Jiashuo Zhang Wanjiang Zhang Qiudong Wang Shengnan Tan Hugh D. C. Smyth |
| author_facet | Xin Hua Qin Yang Zhimin Dong Jiashuo Zhang Wanjiang Zhang Qiudong Wang Shengnan Tan Hugh D. C. Smyth |
| author_sort | Xin Hua |
| collection | DOAJ |
| description | The objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the carboxylic functional groups coating magnetic nanoparticles (fluidMAG-CMX). Following purification of the nanoparticles, the conjugation of DOX on fluidMAG-CMX was confirmed using FTIR spectroscopy and confocal microscopy. The observed drug loading capacity of DOX was 22.3%. Studies of magnetically triggered release were performed under an oscillating magnetic field (OMF). DOX exhibited a significant release percentage of 70% under an OMF, as compared with the release in enzyme. A magnetic field turn-on and turn-off experiment was also conducted to confirm the control of drug release using this triggered system. In vivo experiments indicated that the tumor-inhibitory rate of CMX–DOX NPs under a magnetic field was higher than the other control groups. According to the toxicity assessments, CMX–DOX NPs were not noticeably toxic to mice at our tested dose. |
| first_indexed | 2024-12-22T21:22:49Z |
| format | Article |
| id | doaj.art-3d5680ad73374e44b1672084b85ac235 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-22T21:22:49Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-3d5680ad73374e44b1672084b85ac2352022-12-21T18:12:09ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642017-01-0124151151810.1080/10717544.2016.12560011256001Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatmentXin Hua0Qin Yang1Zhimin Dong2Jiashuo Zhang3Wanjiang Zhang4Qiudong Wang5Shengnan Tan6Hugh D. C. Smyth7State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesTianjin Animal Science and Veterinary Research InstituteCollege of Wildlife Resources, College of Life Science, Northeast Forestry UniversityState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesCollege of Wildlife Resources, College of Life Science, Northeast Forestry UniversityCollege of Pharmacy, The University of Texas at AustinThe objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the carboxylic functional groups coating magnetic nanoparticles (fluidMAG-CMX). Following purification of the nanoparticles, the conjugation of DOX on fluidMAG-CMX was confirmed using FTIR spectroscopy and confocal microscopy. The observed drug loading capacity of DOX was 22.3%. Studies of magnetically triggered release were performed under an oscillating magnetic field (OMF). DOX exhibited a significant release percentage of 70% under an OMF, as compared with the release in enzyme. A magnetic field turn-on and turn-off experiment was also conducted to confirm the control of drug release using this triggered system. In vivo experiments indicated that the tumor-inhibitory rate of CMX–DOX NPs under a magnetic field was higher than the other control groups. According to the toxicity assessments, CMX–DOX NPs were not noticeably toxic to mice at our tested dose.http://dx.doi.org/10.1080/10717544.2016.1256001magnetic nanoparticlesoscillating magnetic fieldcontrolled releasedoxorubicin |
| spellingShingle | Xin Hua Qin Yang Zhimin Dong Jiashuo Zhang Wanjiang Zhang Qiudong Wang Shengnan Tan Hugh D. C. Smyth Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment Drug Delivery magnetic nanoparticles oscillating magnetic field controlled release doxorubicin |
| title | Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment |
| title_full | Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment |
| title_fullStr | Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment |
| title_full_unstemmed | Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment |
| title_short | Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment |
| title_sort | magnetically triggered drug release from nanoparticles and its applications in anti tumor treatment |
| topic | magnetic nanoparticles oscillating magnetic field controlled release doxorubicin |
| url | http://dx.doi.org/10.1080/10717544.2016.1256001 |
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