Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli
Abstract Background H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to dete...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12917-019-1797-9 |
| _version_ | 1811314062326235136 |
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| author | G. G. Bruer P. Hagedorn M. Kietzmann A. F. Tohamy V. Filor E. Schultz S. Mielke-Kuschow J. Meissner |
| author_facet | G. G. Bruer P. Hagedorn M. Kietzmann A. F. Tohamy V. Filor E. Schultz S. Mielke-Kuschow J. Meissner |
| author_sort | G. G. Bruer |
| collection | DOAJ |
| description | Abstract Background H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated with antibacterials in combination with mepyramine. Results The minimum inhibitory concentration (MIC) of E. coli ATCC® 25922™ and E. coli PIG 01 was reduced by combinations of the tested antibacterials with mepyramine. Conclusions These results have to be confirmed in vivo, before the use of antihistamines should be considered as potential way to minimize the amount of used antibacterials for treatment of E. coli infections. |
| first_indexed | 2024-04-13T11:05:16Z |
| format | Article |
| id | doaj.art-3d5a4cbe7cb1432aad267c48a0a09ba3 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-13T11:05:16Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-3d5a4cbe7cb1432aad267c48a0a09ba32022-12-22T02:49:17ZengBMCBMC Veterinary Research1746-61482019-02-011511610.1186/s12917-019-1797-9Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coliG. G. Bruer0P. Hagedorn1M. Kietzmann2A. F. Tohamy3V. Filor4E. Schultz5S. Mielke-Kuschow6J. Meissner7Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover FoundationAbstract Background H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated with antibacterials in combination with mepyramine. Results The minimum inhibitory concentration (MIC) of E. coli ATCC® 25922™ and E. coli PIG 01 was reduced by combinations of the tested antibacterials with mepyramine. Conclusions These results have to be confirmed in vivo, before the use of antihistamines should be considered as potential way to minimize the amount of used antibacterials for treatment of E. coli infections.http://link.springer.com/article/10.1186/s12917-019-1797-9Escherichia coliAntihistaminesAntibacterialsCheckerboard |
| spellingShingle | G. G. Bruer P. Hagedorn M. Kietzmann A. F. Tohamy V. Filor E. Schultz S. Mielke-Kuschow J. Meissner Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli BMC Veterinary Research Escherichia coli Antihistamines Antibacterials Checkerboard |
| title | Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| title_full | Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| title_fullStr | Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| title_full_unstemmed | Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| title_short | Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli |
| title_sort | histamine h1 receptor antagonists enhance the efficacy of antibacterials against escherichia coli |
| topic | Escherichia coli Antihistamines Antibacterials Checkerboard |
| url | http://link.springer.com/article/10.1186/s12917-019-1797-9 |
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