Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus
The effects of nonsteroidal mycotoxin zearalenone on the lymphoid tissue of thymus in a sense of investigating the subacute toxicity Wistar-albino rats have been examined in the course of the study. We analyzed 42 rats' specimens of both gender, treated with three dosage levels: 0,5; 2 and 4 m...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-02-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3093 |
| _version_ | 1797260737516666880 |
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| author | Mirsad Dorić Svjetlana Radović Mirsad Babić Suada Kuskunović Ivana Tomić Ivan Selak |
| author_facet | Mirsad Dorić Svjetlana Radović Mirsad Babić Suada Kuskunović Ivana Tomić Ivan Selak |
| author_sort | Mirsad Dorić |
| collection | DOAJ |
| description |
The effects of nonsteroidal mycotoxin zearalenone on the lymphoid tissue of thymus in a sense of investigating the subacute toxicity Wistar-albino rats have been examined in the course of the study. We analyzed 42 rats' specimens of both gender, treated with three dosage levels: 0,5; 2 and 4 mg/kg of body weight, after oral submission of the compound, and observed during three different time intervals: 10, 20 and 30 days. Microscopically was semiquantitatively determined lymphophagocytosis (apoptosis) and cortical thymic cellularity. It was percepted statistically significant growth of lymphophagocytosis compared to a dosage (p<0,01), as well as combination of dosage and interval (p<0,001), while gender had no statistically significant influence on tested parameter (p>0,05). Changes in cortical thyme cellularity were not percepted. Effects of applied doses of zearalenone on the lymphoid tissue of thymus were very mild and in correlation with estrogenicity. They are probably the result of interaction with estrogenic receptors.
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| first_indexed | 2024-04-24T23:30:05Z |
| format | Article |
| id | doaj.art-3d5a92f7d9ab4c64b070b7df1fefd648 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:30:05Z |
| publishDate | 2007-02-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-3d5a92f7d9ab4c64b070b7df1fefd6482024-03-15T14:42:37ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-02-017110.17305/bjbms.2007.3093663Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s ThymusMirsad Dorić0Svjetlana Radović1Mirsad Babić2Suada Kuskunović3Ivana Tomić4Ivan Selak5Institute of Pathology, Faculty of Medicine, University of SarajevoInstitute of Pathology, Faculty of Medicine, University of SarajevoInstitute of Pathology, Faculty of Medicine, University of SarajevoInstitute of Pathology, Faculty of Medicine, University of SarajevoInstitute of Pathology, Faculty of Medicine, University of SarajevoInstitute of Pathology, Faculty of Medicine, University of Sarajevo The effects of nonsteroidal mycotoxin zearalenone on the lymphoid tissue of thymus in a sense of investigating the subacute toxicity Wistar-albino rats have been examined in the course of the study. We analyzed 42 rats' specimens of both gender, treated with three dosage levels: 0,5; 2 and 4 mg/kg of body weight, after oral submission of the compound, and observed during three different time intervals: 10, 20 and 30 days. Microscopically was semiquantitatively determined lymphophagocytosis (apoptosis) and cortical thymic cellularity. It was percepted statistically significant growth of lymphophagocytosis compared to a dosage (p<0,01), as well as combination of dosage and interval (p<0,001), while gender had no statistically significant influence on tested parameter (p>0,05). Changes in cortical thyme cellularity were not percepted. Effects of applied doses of zearalenone on the lymphoid tissue of thymus were very mild and in correlation with estrogenicity. They are probably the result of interaction with estrogenic receptors. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3093apoptosislymphophagocytosisthymuszearalenone |
| spellingShingle | Mirsad Dorić Svjetlana Radović Mirsad Babić Suada Kuskunović Ivana Tomić Ivan Selak Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus Biomolecules & Biomedicine apoptosis lymphophagocytosis thymus zearalenone |
| title | Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus |
| title_full | Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus |
| title_fullStr | Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus |
| title_full_unstemmed | Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus |
| title_short | Zearalenone-induced Lymphophagocytosis (T Cell Apoptosis) on the Rat’s Thymus |
| title_sort | zearalenone induced lymphophagocytosis t cell apoptosis on the rat s thymus |
| topic | apoptosis lymphophagocytosis thymus zearalenone |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3093 |
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