Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode
The purpose of this work was to construct an electrochemical sensor for the detection of imatinib. It was based on a modified glassy carbon electrode (chitosan/rGO/GCE) that was a reduced graphene oxide nanocomposite. By employing a straightforward drop-casting technique, the rGO/chitosan composite...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Alexandria Engineering Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110016824002187 |
| _version_ | 1797224323228893184 |
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| author | Yongzhi Chen Zhengkai Liu Dousheng Bai |
| author_facet | Yongzhi Chen Zhengkai Liu Dousheng Bai |
| author_sort | Yongzhi Chen |
| collection | DOAJ |
| description | The purpose of this work was to construct an electrochemical sensor for the detection of imatinib. It was based on a modified glassy carbon electrode (chitosan/rGO/GCE) that was a reduced graphene oxide nanocomposite. By employing a straightforward drop-casting technique, the rGO/chitosan composite was applied to the GCE surface. The XRD, FT-IR, and FE-SEM structural studies verified that graphene oxide was successfully reduced and that the rGO/chitosan nanocomposite was formed. The synergistic effect of rGO and chitosan boosted electron transfer kinetics and facilitated the oxidation reaction of imatinib on the electrode surface, according to electrochemical experiments, which indicated the chitosan/rGO/GCE's sensitive, selective, and stable response to imatinib. The findings showed sensitivity of 0.16502 μA/μM, detection limit value of 7.3 nM, and a wide and stable linear range of 1–300 µM. Differential pulse voltammetry measurements were performed on prepared human serum and urine samples to evaluate the applicability of chitosan/rGO/GCE for imatinib detection in real samples. For the prepared genuine samples, the chitosan/rGO/GCE showed good recoveries ranging from 95.00% to 99.20% with a relative standard deviation of 3.10–4.49%. These findings showed that imatinib in a variety of genuine samples may be accurately analyzed using the chitosan/rGO/GCE. |
| first_indexed | 2024-04-24T13:51:17Z |
| format | Article |
| id | doaj.art-3d5e60080bb04f36a8427d72449bb2a3 |
| institution | Directory Open Access Journal |
| issn | 1110-0168 |
| language | English |
| last_indexed | 2024-04-24T13:51:17Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Alexandria Engineering Journal |
| spelling | doaj.art-3d5e60080bb04f36a8427d72449bb2a32024-04-04T05:03:22ZengElsevierAlexandria Engineering Journal1110-01682024-04-01938089Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrodeYongzhi Chen0Zhengkai Liu1Dousheng Bai2Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, ChinaDepartment of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, ChinaDepartment of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China; Corresponding author.The purpose of this work was to construct an electrochemical sensor for the detection of imatinib. It was based on a modified glassy carbon electrode (chitosan/rGO/GCE) that was a reduced graphene oxide nanocomposite. By employing a straightforward drop-casting technique, the rGO/chitosan composite was applied to the GCE surface. The XRD, FT-IR, and FE-SEM structural studies verified that graphene oxide was successfully reduced and that the rGO/chitosan nanocomposite was formed. The synergistic effect of rGO and chitosan boosted electron transfer kinetics and facilitated the oxidation reaction of imatinib on the electrode surface, according to electrochemical experiments, which indicated the chitosan/rGO/GCE's sensitive, selective, and stable response to imatinib. The findings showed sensitivity of 0.16502 μA/μM, detection limit value of 7.3 nM, and a wide and stable linear range of 1–300 µM. Differential pulse voltammetry measurements were performed on prepared human serum and urine samples to evaluate the applicability of chitosan/rGO/GCE for imatinib detection in real samples. For the prepared genuine samples, the chitosan/rGO/GCE showed good recoveries ranging from 95.00% to 99.20% with a relative standard deviation of 3.10–4.49%. These findings showed that imatinib in a variety of genuine samples may be accurately analyzed using the chitosan/rGO/GCE.http://www.sciencedirect.com/science/article/pii/S1110016824002187ChitosanReduced graphene oxideNanocompositeImatinibElectrochemical sensor |
| spellingShingle | Yongzhi Chen Zhengkai Liu Dousheng Bai Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode Alexandria Engineering Journal Chitosan Reduced graphene oxide Nanocomposite Imatinib Electrochemical sensor |
| title | Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode |
| title_full | Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode |
| title_fullStr | Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode |
| title_full_unstemmed | Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode |
| title_short | Determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan/graphene oxide modified electrode |
| title_sort | determination of imatinib as anticancer drug in serum and urine samples by electrochemical technique using a chitosan graphene oxide modified electrode |
| topic | Chitosan Reduced graphene oxide Nanocomposite Imatinib Electrochemical sensor |
| url | http://www.sciencedirect.com/science/article/pii/S1110016824002187 |
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