Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and significant alterations of glycosylation are obser...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02120/full |
| _version_ | 1819102314990927872 |
|---|---|
| author | Heinz Läubli Lubor Borsig Lubor Borsig |
| author_facet | Heinz Läubli Lubor Borsig Lubor Borsig |
| author_sort | Heinz Läubli |
| collection | DOAJ |
| description | Cell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and significant alterations of glycosylation are observed. These changes in cell adhesion molecules alter the ability of tumor cells to interact with other cells and extracellular matrix proteins. Three families of cell-cell interaction molecules selectins, Siglecs, and integrins have been associated with cancer progression in many pre-clinical studies, yet inhibition of cell adhesion as a therapeutic target is just beginning to be explored. We review how cell-cell interactions mediated by integrins and the glycan-binding receptors selectins and Siglec receptors support cancer progression. The discussion focuses on mechanisms during immune evasion and metastasis that can be therapeutically targeted by blocking these cell-cell interactions. |
| first_indexed | 2024-12-22T01:32:36Z |
| format | Article |
| id | doaj.art-3d5fc860e4f64d3b86f2998b9e1f1ccf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T01:32:36Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3d5fc860e4f64d3b86f2998b9e1f1ccf2022-12-21T18:43:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-09-011010.3389/fimmu.2019.02120484841Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and MetastasisHeinz Läubli0Lubor Borsig1Lubor Borsig2Laboratory for Cancer Immunotherapy, Department of Biomedicine and Medical Oncology, Department of Internal Medicine, University Hospital, Basel, SwitzerlandDepartment of Physiology, University of Zurich, Zurich, SwitzerlandComprehensive Cancer Center, Zurich, SwitzerlandCell-cell interactions and cell adhesion are key mediators of cancer progression and facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many cell adhesion molecules within the tumor microenvironment are changed and significant alterations of glycosylation are observed. These changes in cell adhesion molecules alter the ability of tumor cells to interact with other cells and extracellular matrix proteins. Three families of cell-cell interaction molecules selectins, Siglecs, and integrins have been associated with cancer progression in many pre-clinical studies, yet inhibition of cell adhesion as a therapeutic target is just beginning to be explored. We review how cell-cell interactions mediated by integrins and the glycan-binding receptors selectins and Siglec receptors support cancer progression. The discussion focuses on mechanisms during immune evasion and metastasis that can be therapeutically targeted by blocking these cell-cell interactions.https://www.frontiersin.org/article/10.3389/fimmu.2019.02120/fullselectinSiglecintegrinimmunitysialic acidtumor microenvironment |
| spellingShingle | Heinz Läubli Lubor Borsig Lubor Borsig Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis Frontiers in Immunology selectin Siglec integrin immunity sialic acid tumor microenvironment |
| title | Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis |
| title_full | Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis |
| title_fullStr | Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis |
| title_full_unstemmed | Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis |
| title_short | Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis |
| title_sort | altered cell adhesion and glycosylation promote cancer immune suppression and metastasis |
| topic | selectin Siglec integrin immunity sialic acid tumor microenvironment |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02120/full |
| work_keys_str_mv | AT heinzlaubli alteredcelladhesionandglycosylationpromotecancerimmunesuppressionandmetastasis AT luborborsig alteredcelladhesionandglycosylationpromotecancerimmunesuppressionandmetastasis AT luborborsig alteredcelladhesionandglycosylationpromotecancerimmunesuppressionandmetastasis |