Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid
A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2021-04-01
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| Series: | Eclética Química |
| Online Access: | http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1198 |
| _version_ | 1819067769806651392 |
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| author | José Alberto Paris Junior Ana Júlia Salvador Rocchi Bruno Torquato Biagioni Maurício Cavicchioli Rachel Temperani Amaral Machado Fernando Rogério Pavan Pedro Paulo Corbi Wilton Rogério Lustri Douglas Henrique Pereira Antonio Carlos Massabni |
| author_facet | José Alberto Paris Junior Ana Júlia Salvador Rocchi Bruno Torquato Biagioni Maurício Cavicchioli Rachel Temperani Amaral Machado Fernando Rogério Pavan Pedro Paulo Corbi Wilton Rogério Lustri Douglas Henrique Pereira Antonio Carlos Massabni |
| author_sort | José Alberto Paris Junior |
| collection | DOAJ |
| description | A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy. The studies confirmed that each carboxylate group of the succinate anion is coordinated to one silver atom by the two oxygen in a bidentate mode and the bond lengths O···Ag theoretically determined range from 2.325 to 2.338 Å. The complex [Ag2(C4H4O4)] showed in vitro antibacterial activity against the bacterial strains of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa complex. Anti-Mycobacterium tuberculosis analyses were also performed and the [Ag2(C4H4O4)] complex was shown to be active over M. tuberculosis H37Rv strain with MIC90 of 23.94 μg mL-1 while succinic acid itself showed a value higher than 25.00 μg mL-1. |
| first_indexed | 2024-12-21T16:23:31Z |
| format | Article |
| id | doaj.art-3d609044bd074fa1967ea05b04f559c9 |
| institution | Directory Open Access Journal |
| issn | 0100-4670 1678-4618 |
| language | English |
| last_indexed | 2024-12-21T16:23:31Z |
| publishDate | 2021-04-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Eclética Química |
| spelling | doaj.art-3d609044bd074fa1967ea05b04f559c92022-12-21T18:57:30ZengUniversidade Estadual PaulistaEclética Química0100-46701678-46182021-04-01462263510.26850/1678-4618eqj.v46.2.2021.p26-351076Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acidJosé Alberto Paris Junior0Ana Júlia Salvador Rocchi1Bruno Torquato Biagioni2Maurício Cavicchioli3Rachel Temperani Amaral Machado4Fernando Rogério Pavan5Pedro Paulo Corbi6Wilton Rogério Lustri7Douglas Henrique Pereira8Antonio Carlos Massabni9University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil.University of Araraquara, Medicine Course, Araraquara, Brazil.University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil.São Paulo State University, Institute of Chemistry, Araraquara, Brazil.São Paulo State University, School of Pharmaceutical Sciences, Araraquara, Brazil.São Paulo State University, School of Pharmaceutical Sciences, Araraquara, Brazil.University of Campinas, Institute of Chemistry, Campinas, Brazil.University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil.Federal University of Tocantins, Chemistry Collegiate, Gurupi, Brazil.University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil. São Paulo State University, Institute of Chemistry, Araraquara, Brazil.A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy. The studies confirmed that each carboxylate group of the succinate anion is coordinated to one silver atom by the two oxygen in a bidentate mode and the bond lengths O···Ag theoretically determined range from 2.325 to 2.338 Å. The complex [Ag2(C4H4O4)] showed in vitro antibacterial activity against the bacterial strains of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa complex. Anti-Mycobacterium tuberculosis analyses were also performed and the [Ag2(C4H4O4)] complex was shown to be active over M. tuberculosis H37Rv strain with MIC90 of 23.94 μg mL-1 while succinic acid itself showed a value higher than 25.00 μg mL-1.http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1198 |
| spellingShingle | José Alberto Paris Junior Ana Júlia Salvador Rocchi Bruno Torquato Biagioni Maurício Cavicchioli Rachel Temperani Amaral Machado Fernando Rogério Pavan Pedro Paulo Corbi Wilton Rogério Lustri Douglas Henrique Pereira Antonio Carlos Massabni Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid Eclética Química |
| title | Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid |
| title_full | Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid |
| title_fullStr | Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid |
| title_full_unstemmed | Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid |
| title_short | Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid |
| title_sort | chemical spectroscopic characterization molecular modeling and antibacterial activity assays of a silver i complex with succinic acid |
| url | http://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/1198 |
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