Chemistry of Substituted Thiazinanes and Their Derivatives
Thiazinanes and its isomeric forms represent one of the most important heterocyclic compounds, and their derivatives represented a highly potent drug in disease treatment such as, 1,1-dioxido-1,2-thiazinan-1,6-naphthyridine, which has been shown to have anti-HIV activity by a mechanism that should w...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5610 |
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| author | Alaa A. Hassan Stefan Bräse Ashraf A. Aly Hendawy N. Tawfeek |
| author_facet | Alaa A. Hassan Stefan Bräse Ashraf A. Aly Hendawy N. Tawfeek |
| author_sort | Alaa A. Hassan |
| collection | DOAJ |
| description | Thiazinanes and its isomeric forms represent one of the most important heterocyclic compounds, and their derivatives represented a highly potent drug in disease treatment such as, 1,1-dioxido-1,2-thiazinan-1,6-naphthyridine, which has been shown to have anti-HIV activity by a mechanism that should work as anti-AIDS treatment, while (<i>Z</i>)-methyl 3-(naphthalen-1-ylimino)- 2-thia-4-azaspiro[5 5]undecane-4-carbodithioate showed analgesic activity, cephradine was used as antibiotic and chlormezanone was utilized as anticoagulants. All publications were interested in the chemistry of thiazine (partially or fully unsaturated heterocyclic six-membered ring containing nitrogen and sulfur), but no one was dealing with thiazinane itself which encouraged us to shed new light on these interesting heterocycles. This review was focused on the synthetic approaches of thiazinane derivatives and their chemical reactivity. |
| first_indexed | 2024-03-10T14:28:02Z |
| format | Article |
| id | doaj.art-3d6169ddce4c4f419bd3fdb7856accf0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:28:02Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3d6169ddce4c4f419bd3fdb7856accf02023-11-20T22:47:13ZengMDPI AGMolecules1420-30492020-11-012523561010.3390/molecules25235610Chemistry of Substituted Thiazinanes and Their DerivativesAlaa A. Hassan0Stefan Bräse1Ashraf A. Aly2Hendawy N. Tawfeek3Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, GermanyChemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptChemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptThiazinanes and its isomeric forms represent one of the most important heterocyclic compounds, and their derivatives represented a highly potent drug in disease treatment such as, 1,1-dioxido-1,2-thiazinan-1,6-naphthyridine, which has been shown to have anti-HIV activity by a mechanism that should work as anti-AIDS treatment, while (<i>Z</i>)-methyl 3-(naphthalen-1-ylimino)- 2-thia-4-azaspiro[5 5]undecane-4-carbodithioate showed analgesic activity, cephradine was used as antibiotic and chlormezanone was utilized as anticoagulants. All publications were interested in the chemistry of thiazine (partially or fully unsaturated heterocyclic six-membered ring containing nitrogen and sulfur), but no one was dealing with thiazinane itself which encouraged us to shed new light on these interesting heterocycles. This review was focused on the synthetic approaches of thiazinane derivatives and their chemical reactivity.https://www.mdpi.com/1420-3049/25/23/5610biologic activityfused-heterocyclesspiro compoundsstructuresthiazinanes |
| spellingShingle | Alaa A. Hassan Stefan Bräse Ashraf A. Aly Hendawy N. Tawfeek Chemistry of Substituted Thiazinanes and Their Derivatives Molecules biologic activity fused-heterocycles spiro compounds structures thiazinanes |
| title | Chemistry of Substituted Thiazinanes and Their Derivatives |
| title_full | Chemistry of Substituted Thiazinanes and Their Derivatives |
| title_fullStr | Chemistry of Substituted Thiazinanes and Their Derivatives |
| title_full_unstemmed | Chemistry of Substituted Thiazinanes and Their Derivatives |
| title_short | Chemistry of Substituted Thiazinanes and Their Derivatives |
| title_sort | chemistry of substituted thiazinanes and their derivatives |
| topic | biologic activity fused-heterocycles spiro compounds structures thiazinanes |
| url | https://www.mdpi.com/1420-3049/25/23/5610 |
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