Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe.
Genome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations.In this study, we analysed almost 250,000 SNPs from a total of 945 samples from Eastern and Western Finland, Sweden, Northern Germany and Great Britain complemented with HapMap dat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2567036?pdf=render |
| _version_ | 1819134622087249920 |
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| author | Elina Salmela Tuuli Lappalainen Ingegerd Fransson Peter M Andersen Karin Dahlman-Wright Andreas Fiebig Pertti Sistonen Marja-Liisa Savontaus Stefan Schreiber Juha Kere Päivi Lahermo |
| author_facet | Elina Salmela Tuuli Lappalainen Ingegerd Fransson Peter M Andersen Karin Dahlman-Wright Andreas Fiebig Pertti Sistonen Marja-Liisa Savontaus Stefan Schreiber Juha Kere Päivi Lahermo |
| author_sort | Elina Salmela |
| collection | DOAJ |
| description | Genome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations.In this study, we analysed almost 250,000 SNPs from a total of 945 samples from Eastern and Western Finland, Sweden, Northern Germany and Great Britain complemented with HapMap data. Small but statistically significant differences were observed between the European populations (F(ST) = 0.0040, p<10(-4)), also between Eastern and Western Finland (F(ST) = 0.0032, p<10(-3)). The latter indicated the existence of a relatively strong autosomal substructure within the country, similar to that observed earlier with smaller numbers of markers. The Germans and British were less differentiated than the Swedes, Western Finns and especially the Eastern Finns who also showed other signs of genetic drift. This is likely caused by the later founding of the northern populations, together with subsequent founder and bottleneck effects, and a smaller population size. Furthermore, our data suggest a small eastern contribution among the Finns, consistent with the historical and linguistic background of the population.Our results warn against a priori assumptions of homogeneity among Finns and other seemingly isolated populations. Thus, in association studies in such populations, additional caution for population structure may be necessary. Our results illustrate that population history is often important for patterns of genetic variation, and that the analysis of hundreds of thousands of SNPs provides high resolution also for population genetics. |
| first_indexed | 2024-12-22T10:06:07Z |
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| id | doaj.art-3d61a3dd41114a7c9ca00a3dfc33a4e3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T10:06:07Z |
| publishDate | 2008-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3d61a3dd41114a7c9ca00a3dfc33a4e32022-12-21T18:29:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-01-01310e351910.1371/journal.pone.0003519Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe.Elina SalmelaTuuli LappalainenIngegerd FranssonPeter M AndersenKarin Dahlman-WrightAndreas FiebigPertti SistonenMarja-Liisa SavontausStefan SchreiberJuha KerePäivi LahermoGenome-wide data provide a powerful tool for inferring patterns of genetic variation and structure of human populations.In this study, we analysed almost 250,000 SNPs from a total of 945 samples from Eastern and Western Finland, Sweden, Northern Germany and Great Britain complemented with HapMap data. Small but statistically significant differences were observed between the European populations (F(ST) = 0.0040, p<10(-4)), also between Eastern and Western Finland (F(ST) = 0.0032, p<10(-3)). The latter indicated the existence of a relatively strong autosomal substructure within the country, similar to that observed earlier with smaller numbers of markers. The Germans and British were less differentiated than the Swedes, Western Finns and especially the Eastern Finns who also showed other signs of genetic drift. This is likely caused by the later founding of the northern populations, together with subsequent founder and bottleneck effects, and a smaller population size. Furthermore, our data suggest a small eastern contribution among the Finns, consistent with the historical and linguistic background of the population.Our results warn against a priori assumptions of homogeneity among Finns and other seemingly isolated populations. Thus, in association studies in such populations, additional caution for population structure may be necessary. Our results illustrate that population history is often important for patterns of genetic variation, and that the analysis of hundreds of thousands of SNPs provides high resolution also for population genetics.http://europepmc.org/articles/PMC2567036?pdf=render |
| spellingShingle | Elina Salmela Tuuli Lappalainen Ingegerd Fransson Peter M Andersen Karin Dahlman-Wright Andreas Fiebig Pertti Sistonen Marja-Liisa Savontaus Stefan Schreiber Juha Kere Päivi Lahermo Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS ONE |
| title | Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. |
| title_full | Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. |
| title_fullStr | Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. |
| title_full_unstemmed | Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. |
| title_short | Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. |
| title_sort | genome wide analysis of single nucleotide polymorphisms uncovers population structure in northern europe |
| url | http://europepmc.org/articles/PMC2567036?pdf=render |
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