Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses.

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses.

The host innate immune response mediated by type I interferon (IFN) and the resulting up-regulation of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to virus infection. Studies of the type I 'interferome' have mainly been carried out at a single species level,...

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Bibliographic Details
Main Authors: Andrew E Shaw, Joseph Hughes, Quan Gu, Abdelkader Behdenna, Joshua B Singer, Tristan Dennis, Richard J Orton, Mariana Varela, Robert J Gifford, Sam J Wilson, Massimo Palmarini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2004086

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