Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele
The amygdala is known to be related to cognitive function. In this study, we used an automated approach to segment the amygdala into nine nuclei and evaluated amygdala and nuclei volumetric changes across the adult lifespan in subjects carrying the apolipoprotein E (ApoE) ε3/ε3 allele, and we relate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.747288/full |
| _version_ | 1811189386290659328 |
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| author | Wenqing Liao Dong Cui Jingna Jin Wenbo Liu Xin Wang He Wang Ying Li Zhipeng Liu Tao Yin Tao Yin |
| author_facet | Wenqing Liao Dong Cui Jingna Jin Wenbo Liu Xin Wang He Wang Ying Li Zhipeng Liu Tao Yin Tao Yin |
| author_sort | Wenqing Liao |
| collection | DOAJ |
| description | The amygdala is known to be related to cognitive function. In this study, we used an automated approach to segment the amygdala into nine nuclei and evaluated amygdala and nuclei volumetric changes across the adult lifespan in subjects carrying the apolipoprotein E (ApoE) ε3/ε3 allele, and we related those changes to memory function alteration. We found that except the left medial nucleus (Me), whose volume decreased in the old group compared with the middle-early group, all other nuclei volumes presented a significant decline in the old group compared with the young group. Left accessory basal nucleus (AB) and left cortico-amygdaloid transition area (CAT) volumes were also diminished in the middle-late group. In addition, immediate memory recall is impaired by the process of aging, whereas delayed recall and delayed recognition memory functions were not significantly changed. We found significant positive correlations between immediate recall scores and volumes of the bilateral basal nucleus (Ba), AB, anterior amygdaloid area (AAA), CAT, whole amygdala, left lateral nucleus (La), left paralaminar nucleus (PL), and right cortical nucleus (Co). The results suggest that immediate recall memory decline might be associated with volumetric reduction of the amygdala and its nuclei, and the left AB and left CAT might be considered as potential imaging biomarkers of memory decline in aging. |
| first_indexed | 2024-04-11T14:35:01Z |
| format | Article |
| id | doaj.art-3d61f8d54bde43f28d7c10885857f3a5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T14:35:01Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3d61f8d54bde43f28d7c10885857f3a52022-12-22T04:18:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-12-011310.3389/fnagi.2021.747288747288Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 AlleleWenqing Liao0Dong Cui1Jingna Jin2Wenbo Liu3Xin Wang4He Wang5Ying Li6Zhipeng Liu7Tao Yin8Tao Yin9Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaSinovation (Beijing) Medical Technology Co., Ltd., Beijing, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, ChinaNeuroscience Center, Chinese Academy of Medical Sciences, Beijing, ChinaThe amygdala is known to be related to cognitive function. In this study, we used an automated approach to segment the amygdala into nine nuclei and evaluated amygdala and nuclei volumetric changes across the adult lifespan in subjects carrying the apolipoprotein E (ApoE) ε3/ε3 allele, and we related those changes to memory function alteration. We found that except the left medial nucleus (Me), whose volume decreased in the old group compared with the middle-early group, all other nuclei volumes presented a significant decline in the old group compared with the young group. Left accessory basal nucleus (AB) and left cortico-amygdaloid transition area (CAT) volumes were also diminished in the middle-late group. In addition, immediate memory recall is impaired by the process of aging, whereas delayed recall and delayed recognition memory functions were not significantly changed. We found significant positive correlations between immediate recall scores and volumes of the bilateral basal nucleus (Ba), AB, anterior amygdaloid area (AAA), CAT, whole amygdala, left lateral nucleus (La), left paralaminar nucleus (PL), and right cortical nucleus (Co). The results suggest that immediate recall memory decline might be associated with volumetric reduction of the amygdala and its nuclei, and the left AB and left CAT might be considered as potential imaging biomarkers of memory decline in aging.https://www.frontiersin.org/articles/10.3389/fnagi.2021.747288/fullamygdala nucleiagingApoEimmediate recalldelayed recalldelayed recognition |
| spellingShingle | Wenqing Liao Dong Cui Jingna Jin Wenbo Liu Xin Wang He Wang Ying Li Zhipeng Liu Tao Yin Tao Yin Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele Frontiers in Aging Neuroscience amygdala nuclei aging ApoE immediate recall delayed recall delayed recognition |
| title | Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele |
| title_full | Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele |
| title_fullStr | Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele |
| title_full_unstemmed | Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele |
| title_short | Correlation Between Amygdala Nuclei Volumes and Memory in Cognitively Normal Adults Carrying the ApoE ε3/ε3 Allele |
| title_sort | correlation between amygdala nuclei volumes and memory in cognitively normal adults carrying the apoe ε3 ε3 allele |
| topic | amygdala nuclei aging ApoE immediate recall delayed recall delayed recognition |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.747288/full |
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