Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
The bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26847-y |
| _version_ | 1831677256139800576 |
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| author | Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki |
| author_facet | Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki |
| author_sort | Benjamin Kostiuk |
| collection | DOAJ |
| description | The bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes that disadvantaged them when confronted with 7th pandemic El Tor biotype strains. |
| first_indexed | 2024-12-20T04:38:27Z |
| format | Article |
| id | doaj.art-3d629ab816704df4bbda22e3c61d8c4a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T04:38:27Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3d629ab816704df4bbda22e3c61d8c4a2022-12-21T19:53:11ZengNature PortfolioNature Communications2041-17232021-11-0112111110.1038/s41467-021-26847-yType VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotypeBenjamin Kostiuk0Francis J. Santoriello1Laura Diaz-Satizabal2Fabiana Bisaro3Kyung-Jo Lee4Anna N. Dhody5Daniele Provenzano6Daniel Unterweger7Stefan Pukatzki8Department of Medical Microbiology and Immunology, 6-020 Katz Group Centre, University of AlbertaDepartment of Immunology & Microbiology, University of Colorado Denver Anschutz Medical CampusDepartment of Medical Microbiology and Immunology, 6-020 Katz Group Centre, University of AlbertaDepartment of Biology, The City College of New YorkDepartment of Biology, The City College of New YorkMütter Research Institute, The College of Physicians of PhiladelphiaDepartment of Biology, University of Texas Rio Grande Valley, One West University BlvdMax-Planck Institute for Evolutionary BiologyDepartment of Biology, The City College of New YorkThe bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes that disadvantaged them when confronted with 7th pandemic El Tor biotype strains.https://doi.org/10.1038/s41467-021-26847-y |
| spellingShingle | Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype Nature Communications |
| title | Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype |
| title_full | Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype |
| title_fullStr | Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype |
| title_full_unstemmed | Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype |
| title_short | Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype |
| title_sort | type vi secretion system mutations reduced competitive fitness of classical vibrio cholerae biotype |
| url | https://doi.org/10.1038/s41467-021-26847-y |
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