Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice
Objectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Archives of Medicine and Health Sciences |
| Subjects: | |
| Online Access: | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2013;volume=1;issue=1;spage=6;epage=9;aulast=Joy |
| _version_ | 1828307660074647552 |
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| author | Anu Elizabeth Joy Shankar Bhat Kunhikatta Shyamjith Manikkoth |
| author_facet | Anu Elizabeth Joy Shankar Bhat Kunhikatta Shyamjith Manikkoth |
| author_sort | Anu Elizabeth Joy |
| collection | DOAJ |
| description | Objectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (200 mg/kg, i.p) was studied for its anti-convulsant effect on MES and PTZ-induced seizures in Swiss albino mice. In MES seizures, suppression of tonic hind limb extension was noted. In PTZ seizures, abolition of the convulsions was noted. Results : The ethanolic extract of the leaves of Moringa concanensis (200 mg/kg, i.p) significantly (P < 0.001) abolished the hind limb extension induced by MES. The same dose also significantly (P < 0.001) protected the animals from PTZ-induced tonic convulsions. Conclusion : The data suggests that the ethanolic extract of Moringa concanensis leaves may produce its anti-convulsant effects via multiple mechanisms since it abolished the hind limb extension induced by MES as well as abolished seizures produced by PTZ. |
| first_indexed | 2024-04-13T15:01:01Z |
| format | Article |
| id | doaj.art-3d63013c9313479b96410e4f99208c3f |
| institution | Directory Open Access Journal |
| issn | 2321-4848 |
| language | English |
| last_indexed | 2024-04-13T15:01:01Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Archives of Medicine and Health Sciences |
| spelling | doaj.art-3d63013c9313479b96410e4f99208c3f2022-12-22T02:42:17ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482013-01-01116910.4103/2321-4848.113548Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino miceAnu Elizabeth JoyShankar Bhat KunhikattaShyamjith ManikkothObjectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (200 mg/kg, i.p) was studied for its anti-convulsant effect on MES and PTZ-induced seizures in Swiss albino mice. In MES seizures, suppression of tonic hind limb extension was noted. In PTZ seizures, abolition of the convulsions was noted. Results : The ethanolic extract of the leaves of Moringa concanensis (200 mg/kg, i.p) significantly (P < 0.001) abolished the hind limb extension induced by MES. The same dose also significantly (P < 0.001) protected the animals from PTZ-induced tonic convulsions. Conclusion : The data suggests that the ethanolic extract of Moringa concanensis leaves may produce its anti-convulsant effects via multiple mechanisms since it abolished the hind limb extension induced by MES as well as abolished seizures produced by PTZ.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2013;volume=1;issue=1;spage=6;epage=9;aulast=JoyAnti-convulsantethanolic extractMoringa concanensisSwiss albino mice |
| spellingShingle | Anu Elizabeth Joy Shankar Bhat Kunhikatta Shyamjith Manikkoth Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice Archives of Medicine and Health Sciences Anti-convulsant ethanolic extract Moringa concanensis Swiss albino mice |
| title | Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice |
| title_full | Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice |
| title_fullStr | Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice |
| title_full_unstemmed | Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice |
| title_short | Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice |
| title_sort | anti convulsant activity of ethanolic extract of moringa concanensis leaves in swiss albino mice |
| topic | Anti-convulsant ethanolic extract Moringa concanensis Swiss albino mice |
| url | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2013;volume=1;issue=1;spage=6;epage=9;aulast=Joy |
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