Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes
Human phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to i...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/10/8931 |
| _version_ | 1797599726450769920 |
|---|---|
| author | Kinga Humińska-Lisowska Krzysztof Chmielowiec Aleksandra Strońska-Pluta Jolanta Chmielowiec Aleksandra Suchanecka Jolanta Masiak Monika Michałowska-Sawczyn Agnieszka Boroń Paweł Cięszczyk Anna Grzywacz |
| author_facet | Kinga Humińska-Lisowska Krzysztof Chmielowiec Aleksandra Strońska-Pluta Jolanta Chmielowiec Aleksandra Suchanecka Jolanta Masiak Monika Michałowska-Sawczyn Agnieszka Boroń Paweł Cięszczyk Anna Grzywacz |
| author_sort | Kinga Humińska-Lisowska |
| collection | DOAJ |
| description | Human phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to investigate the association between methylation in the promoter region of the <i>DAT1</i> gene and personality traits measured by the NEO-FFI questionnaire in a group of athletes. The study group included 163 athletes, and the control group consisted of 232 non-athletes. The obtained results show several significant differences between the studied groups of subjects. The Extraversion scale and the Conscientiousness scale results of the NEO-FFI are significantly higher in the group of athletes compared to controls. The total methylation and the number of methylated islands in the promoter region of the <i>DAT1</i> gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. The total methylation and the number of methylated islands in the promoter region of the <i>DAT1</i> gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. Our analysis of the methylation status of individual CpG sites revealed a new direction of research into the biological aspects of regulating dopamine release and personality traits in people practicing sports. |
| first_indexed | 2024-03-11T03:39:24Z |
| format | Article |
| id | doaj.art-3d63dafdc1ee459089c846bb50e27d68 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:39:24Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3d63dafdc1ee459089c846bb50e27d682023-11-18T01:44:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410893110.3390/ijms24108931Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in AthletesKinga Humińska-Lisowska0Krzysztof Chmielowiec1Aleksandra Strońska-Pluta2Jolanta Chmielowiec3Aleksandra Suchanecka4Jolanta Masiak5Monika Michałowska-Sawczyn6Agnieszka Boroń7Paweł Cięszczyk8Anna Grzywacz9Faculty of Physical Education, Gdansk University of Physical Education and Sport, K. Górskiego St. 1, 80-336 Gdansk, PolandDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, PolandIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, PolandDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, PolandIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, PolandSecond Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 1 Głuska St., 20-059 Lublin, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, K. Górskiego St. 1, 80-336 Gdansk, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, Aleja Powstańców Wielkopolskich 72 St., 70-111 Szczecin, PolandFaculty of Physical Education, Gdansk University of Physical Education and Sport, K. Górskiego St. 1, 80-336 Gdansk, PolandIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, PolandHuman phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to investigate the association between methylation in the promoter region of the <i>DAT1</i> gene and personality traits measured by the NEO-FFI questionnaire in a group of athletes. The study group included 163 athletes, and the control group consisted of 232 non-athletes. The obtained results show several significant differences between the studied groups of subjects. The Extraversion scale and the Conscientiousness scale results of the NEO-FFI are significantly higher in the group of athletes compared to controls. The total methylation and the number of methylated islands in the promoter region of the <i>DAT1</i> gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. The total methylation and the number of methylated islands in the promoter region of the <i>DAT1</i> gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. Our analysis of the methylation status of individual CpG sites revealed a new direction of research into the biological aspects of regulating dopamine release and personality traits in people practicing sports.https://www.mdpi.com/1422-0067/24/10/8931dopamine transporter<i>DAT1</i>methylationathletes |
| spellingShingle | Kinga Humińska-Lisowska Krzysztof Chmielowiec Aleksandra Strońska-Pluta Jolanta Chmielowiec Aleksandra Suchanecka Jolanta Masiak Monika Michałowska-Sawczyn Agnieszka Boroń Paweł Cięszczyk Anna Grzywacz Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes International Journal of Molecular Sciences dopamine transporter <i>DAT1</i> methylation athletes |
| title | Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes |
| title_full | Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes |
| title_fullStr | Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes |
| title_full_unstemmed | Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes |
| title_short | Epigenetic Analysis of the Dopamine Transporter Gene <i>DAT1</i> with a Focus on Personality Traits in Athletes |
| title_sort | epigenetic analysis of the dopamine transporter gene i dat1 i with a focus on personality traits in athletes |
| topic | dopamine transporter <i>DAT1</i> methylation athletes |
| url | https://www.mdpi.com/1422-0067/24/10/8931 |
| work_keys_str_mv | AT kingahuminskalisowska epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT krzysztofchmielowiec epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT aleksandrastronskapluta epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT jolantachmielowiec epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT aleksandrasuchanecka epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT jolantamasiak epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT monikamichałowskasawczyn epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT agnieszkaboron epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT pawełcieszczyk epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes AT annagrzywacz epigeneticanalysisofthedopaminetransportergeneidat1iwithafocusonpersonalitytraitsinathletes |