Biological Assay-Guided Fractionation and Mass Spectrometry-Based Metabolite Profiling of <i>Annona muricata</i> L. Cytotoxic Compounds against Lung Cancer A549 Cell Line

Biological Assay-Guided Fractionation and Mass Spectrometry-Based Metabolite Profiling of <i>Annona muricata</i> L. Cytotoxic Compounds against Lung Cancer A549 Cell Line

<i>Annona muricata</i> L. (Guyabano) leaves are reported to exhibit anticancer activity against cancer cells. In this study, the ethyl acetate extract from guyabano leaves was purified through column chromatography, and the cytotoxic effects of the semi-purified fractions were evaluated...

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Bibliographic Details
Main Authors: Edcyl Lee O. Salac, Michael Russelle Alvarez, Rnie Shayne Gaurana, Sheryl Joyce B. Grijaldo, Luster Mae Serrano, Florence de Juan, Rowell Abogado, Isagani Padolina Jr., Froila Marie Deniega, Kimberly Delica, Kimberly Fernandez, Carlito B. Lebrilla, Marlon N. Manalo, Francisco M. Heralde III, Gladys Cherisse J. Completo, Ruel C. Nacario
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Plants
Subjects:
<i>Annona muricata</i>
lung cancer
metabolomics
cytotoxicity
Online Access:https://www.mdpi.com/2223-7747/11/18/2380

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