Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α

Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α

Mitotane is the cornerstone of medical treatment of adrenocortical carcinoma. Estrogenic-like side effects frequently occur in patients, and previous studies explored the chemical nature of the interaction between estrogen receptor-α (ER-α) and toxic compounds, including the DDD derivatives. We used...

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Bibliographic Details
Main Authors: Elisa Rossini, Edoardo Giacopuzzi, Fabrizio Gangemi, Mariangela Tamburello, Deborah Cosentini, Andrea Abate, Marta Laganà, Alfredo Berruti, Salvatore Grisanti, Sandra Sigala
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
estrogen receptor α
mitotane
adrenocortical carcinoma
bioinformatics analysis
Online Access:https://www.mdpi.com/2227-9059/9/6/681

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