Predictors of Outcome following Stroke due to Isolated M2 Occlusions
Background: Factors influencing outcome after cerebral artery occlusion are not completely understood. Although it is well accepted that the site of arterial occlusion critically influences outcome, the majority of studies investigating this issue has focused on proximal large artery occlusion. To g...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-03-01
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| Series: | Cerebrovascular Diseases Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/360075 |
| _version_ | 1819084652712820736 |
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| author | Muhib Khan Richard P. Goddeau Jr. Jayne Zhang Majaz Moonis Nils Henninger |
| author_facet | Muhib Khan Richard P. Goddeau Jr. Jayne Zhang Majaz Moonis Nils Henninger |
| author_sort | Muhib Khan |
| collection | DOAJ |
| description | Background: Factors influencing outcome after cerebral artery occlusion are not completely understood. Although it is well accepted that the site of arterial occlusion critically influences outcome, the majority of studies investigating this issue has focused on proximal large artery occlusion. To gain a better understanding of factors influencing outcome after distal large artery occlusion, we sought to assess predictors of outcome following isolated M2 middle cerebral artery occlusion infarcts. Methods: We retrospectively analyzed patients with isolated acute M2 occlusion admitted to a single academic center from January 2010 to August 2012. Baseline clinical, laboratory imaging, and outcome data were assessed from a prospectively collected database. Factors associated with a modified Rankin Scale (mRS) score ≤2 in univariable analyses (p Results: 90 patients with isolated M2 occlusion were included in the final analyses. Of these, 69% had a good 90-day outcome which was associated with age 28 ml (OR 11.874, 95% CI 2.630-53.604, p = 0.001), age >80 years (OR 4.953, 95% CI 1.087-22.563, p = 0.039), need for intubation (OR 7.788, 95% CI 1.072-56.604), and history of congestive heart failure (OR 5.819, 95% CI 1.140-29.695) were independent predictors of 90-day mortality (20% of all included patients). Conclusion: While the majority of patients with isolated M2 occlusion stroke has a good 90-day outcome, a substantial proportion of subjects dies by 90 days, as identified by a unique subset of predictors. The knowledge gained from our study may lead to an improvement in the prognostic accuracy, clinical management, and resource utilization in this patient population. |
| first_indexed | 2024-12-21T20:51:52Z |
| format | Article |
| id | doaj.art-3d693e5601f44abbaa8b5badb3ce33d2 |
| institution | Directory Open Access Journal |
| issn | 1664-5456 |
| language | English |
| last_indexed | 2024-12-21T20:51:52Z |
| publishDate | 2014-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Cerebrovascular Diseases Extra |
| spelling | doaj.art-3d693e5601f44abbaa8b5badb3ce33d22022-12-21T18:50:41ZengKarger PublishersCerebrovascular Diseases Extra1664-54562014-03-0141526010.1159/000360075360075Predictors of Outcome following Stroke due to Isolated M2 OcclusionsMuhib KhanRichard P. Goddeau Jr.Jayne ZhangMajaz MoonisNils HenningerBackground: Factors influencing outcome after cerebral artery occlusion are not completely understood. Although it is well accepted that the site of arterial occlusion critically influences outcome, the majority of studies investigating this issue has focused on proximal large artery occlusion. To gain a better understanding of factors influencing outcome after distal large artery occlusion, we sought to assess predictors of outcome following isolated M2 middle cerebral artery occlusion infarcts. Methods: We retrospectively analyzed patients with isolated acute M2 occlusion admitted to a single academic center from January 2010 to August 2012. Baseline clinical, laboratory imaging, and outcome data were assessed from a prospectively collected database. Factors associated with a modified Rankin Scale (mRS) score ≤2 in univariable analyses (p Results: 90 patients with isolated M2 occlusion were included in the final analyses. Of these, 69% had a good 90-day outcome which was associated with age 28 ml (OR 11.874, 95% CI 2.630-53.604, p = 0.001), age >80 years (OR 4.953, 95% CI 1.087-22.563, p = 0.039), need for intubation (OR 7.788, 95% CI 1.072-56.604), and history of congestive heart failure (OR 5.819, 95% CI 1.140-29.695) were independent predictors of 90-day mortality (20% of all included patients). Conclusion: While the majority of patients with isolated M2 occlusion stroke has a good 90-day outcome, a substantial proportion of subjects dies by 90 days, as identified by a unique subset of predictors. The knowledge gained from our study may lead to an improvement in the prognostic accuracy, clinical management, and resource utilization in this patient population.http://www.karger.com/Article/FullText/360075OutcomeCortical infarctM2 occlusionStrokeThrombolysis |
| spellingShingle | Muhib Khan Richard P. Goddeau Jr. Jayne Zhang Majaz Moonis Nils Henninger Predictors of Outcome following Stroke due to Isolated M2 Occlusions Cerebrovascular Diseases Extra Outcome Cortical infarct M2 occlusion Stroke Thrombolysis |
| title | Predictors of Outcome following Stroke due to Isolated M2 Occlusions |
| title_full | Predictors of Outcome following Stroke due to Isolated M2 Occlusions |
| title_fullStr | Predictors of Outcome following Stroke due to Isolated M2 Occlusions |
| title_full_unstemmed | Predictors of Outcome following Stroke due to Isolated M2 Occlusions |
| title_short | Predictors of Outcome following Stroke due to Isolated M2 Occlusions |
| title_sort | predictors of outcome following stroke due to isolated m2 occlusions |
| topic | Outcome Cortical infarct M2 occlusion Stroke Thrombolysis |
| url | http://www.karger.com/Article/FullText/360075 |
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