Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity

Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity

Triphenyl phosphate (TPhP) serves as a major organophosphorus flame retardant, and its induced neurodevelopmental toxicity has attracted widespread attention, but the mechanism remains unclear. In this study, we involved zebrafish to explore the new mechanism of TPhP inducing oxidative stress and fe...

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Bibliographic Details
Main Authors: Qiong Zhang, Congying Luo, Zhikang Li, Wenlong Huang, Shukai Zheng, Caixia Liu, Xiaoling Shi, Yikai Ma, Qingqing Ni, Wei Tan, Jiajun Peng, Yuequn Chen, Wenying Wu, Jiejie Li, Kusheng Wu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Triphenyl phosphate (TPhP)
Neurotoxicity
Nrf2/Keap1/HO-1 signaling pathway
Astaxanthin
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000356

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http://www.sciencedirect.com/science/article/pii/S0147651324000356

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