The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study
The aim of the study was to evaluate changes in the retinal thickness and microvasculature based on optical coherence tomography (OCT) depending on baseline oxygen saturation (SpO2) in patients hospitalized due to COVID-19 bilateral pneumonia. The prospective study was carried out among 62 patients...
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1824 |
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| author | Magdalena Kal Mateusz Winiarczyk Jerzy Mackiewicz Dominik Odrobina Elżbieta Cieśla Bernadetta Płatkowska-Adamska Michał Biskup Paweł Pabjan Dorota Zarębska-Michaluk |
| author_facet | Magdalena Kal Mateusz Winiarczyk Jerzy Mackiewicz Dominik Odrobina Elżbieta Cieśla Bernadetta Płatkowska-Adamska Michał Biskup Paweł Pabjan Dorota Zarębska-Michaluk |
| author_sort | Magdalena Kal |
| collection | DOAJ |
| description | The aim of the study was to evaluate changes in the retinal thickness and microvasculature based on optical coherence tomography (OCT) depending on baseline oxygen saturation (SpO2) in patients hospitalized due to COVID-19 bilateral pneumonia. The prospective study was carried out among 62 patients with COVID-19 pneumonia who underwent ophthalmic examination after hospital discharge. They were divided into three groups depending on the oxygen saturation (SpO2) on admission: ≤90% (group 1), >90% and ≤95% (group 2), and >95% (group 3). The following parameters were assessed in the ophthalmological examination and correlated with the baseline SpO2: ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL) in the macular area, RNFL in the peripapillary area, the foveal avascular zone (FAZ) in superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) in SCP, in DCP, and in the choriocapillaris plexus (CC). Baseline saturation ≤90% in COVID-19 patients caused a decrease of VD in some areas of SCP and DCP and an increase in FAZ area in SCP and DCP. In the group of patients with SpO2 ≤ 90% statistically significant thinning of the retina in the inner superior ring (ISR) (<i>p</i> = 0.029), the inner temporal ring (ITR) (<i>p</i> = 0.34), the outer superior ring (OSR) (<i>p</i> = 0.012), and the outer temporal ring (OTR) (<i>p</i>= 0.004)] was observed. The statistically significant thickening of RNFL optic disc and thinning of RNFL retina in some macular areas in patients with SpO2 ≤ 90% were reported. The size of FAZ area in SCP and vessel density were significantly greater in some areas of SCP, DCP, and CC in patients with SpO2 ≤ 90% (<i>p</i> = 0.025). Baseline oxygen saturation ≤90% has been found to influence the ocular parameters of OCT in COVID-19 patients. We noticed a widened FAZ zone in SCP and increased VD in some regions of the retina and choroid as a response to systemic hypoxia. |
| first_indexed | 2024-03-09T18:55:33Z |
| format | Article |
| id | doaj.art-3d6d5d45e3fb469ba30950ef8a7ee4f9 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:55:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-3d6d5d45e3fb469ba30950ef8a7ee4f92023-11-24T05:25:47ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011211182410.3390/jpm12111824The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography StudyMagdalena Kal0Mateusz Winiarczyk1Jerzy Mackiewicz2Dominik Odrobina3Elżbieta Cieśla4Bernadetta Płatkowska-Adamska5Michał Biskup6Paweł Pabjan7Dorota Zarębska-Michaluk8Collegium Medicum of Jan Kochanowski University in Kielce, 25-369 Kielce, PolandDepartment of Vitreoretinal Surgery, Medical University of Lublin, 20-079 Lublin, PolandDepartment of Vitreoretinal Surgery, Medical University of Lublin, 20-079 Lublin, PolandOphthalmic Clinic of the Voivodeship Hospital in Kielce, 25-736 Kielce, PolandInsitute of Medical Science of Jan Kochanowski University in Kielce, 25-369 Kielce, PolandCollegium Medicum of Jan Kochanowski University in Kielce, 25-369 Kielce, PolandOphthalmic Clinic of the Voivodeship Hospital in Kielce, 25-736 Kielce, PolandInsitute of Medical Science of Jan Kochanowski University in Kielce, 25-369 Kielce, PolandCollegium Medicum of Jan Kochanowski University in Kielce, 25-369 Kielce, PolandThe aim of the study was to evaluate changes in the retinal thickness and microvasculature based on optical coherence tomography (OCT) depending on baseline oxygen saturation (SpO2) in patients hospitalized due to COVID-19 bilateral pneumonia. The prospective study was carried out among 62 patients with COVID-19 pneumonia who underwent ophthalmic examination after hospital discharge. They were divided into three groups depending on the oxygen saturation (SpO2) on admission: ≤90% (group 1), >90% and ≤95% (group 2), and >95% (group 3). The following parameters were assessed in the ophthalmological examination and correlated with the baseline SpO2: ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL) in the macular area, RNFL in the peripapillary area, the foveal avascular zone (FAZ) in superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) in SCP, in DCP, and in the choriocapillaris plexus (CC). Baseline saturation ≤90% in COVID-19 patients caused a decrease of VD in some areas of SCP and DCP and an increase in FAZ area in SCP and DCP. In the group of patients with SpO2 ≤ 90% statistically significant thinning of the retina in the inner superior ring (ISR) (<i>p</i> = 0.029), the inner temporal ring (ITR) (<i>p</i> = 0.34), the outer superior ring (OSR) (<i>p</i> = 0.012), and the outer temporal ring (OTR) (<i>p</i>= 0.004)] was observed. The statistically significant thickening of RNFL optic disc and thinning of RNFL retina in some macular areas in patients with SpO2 ≤ 90% were reported. The size of FAZ area in SCP and vessel density were significantly greater in some areas of SCP, DCP, and CC in patients with SpO2 ≤ 90% (<i>p</i> = 0.025). Baseline oxygen saturation ≤90% has been found to influence the ocular parameters of OCT in COVID-19 patients. We noticed a widened FAZ zone in SCP and increased VD in some regions of the retina and choroid as a response to systemic hypoxia.https://www.mdpi.com/2075-4426/12/11/1824retinal microvasculatureOCTOCTACOVID-19SARS-CoV-2optical coherence tomography angiography |
| spellingShingle | Magdalena Kal Mateusz Winiarczyk Jerzy Mackiewicz Dominik Odrobina Elżbieta Cieśla Bernadetta Płatkowska-Adamska Michał Biskup Paweł Pabjan Dorota Zarębska-Michaluk The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study Journal of Personalized Medicine retinal microvasculature OCT OCTA COVID-19 SARS-CoV-2 optical coherence tomography angiography |
| title | The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study |
| title_full | The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study |
| title_fullStr | The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study |
| title_full_unstemmed | The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study |
| title_short | The Effect of Reduced Oxygen Saturation on Retinal Microvascularization in COVID-19 Patients with Bilateral Pneumonia Based on Optical Coherence Tomography Study |
| title_sort | effect of reduced oxygen saturation on retinal microvascularization in covid 19 patients with bilateral pneumonia based on optical coherence tomography study |
| topic | retinal microvasculature OCT OCTA COVID-19 SARS-CoV-2 optical coherence tomography angiography |
| url | https://www.mdpi.com/2075-4426/12/11/1824 |
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