Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda

Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization.Methods: We enrolled 132 LTBI-positive and 150 LTBI-negative...

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Bibliographic Details
Main Authors: Lawrence Lubyayi, Patrice A. Mawa, Grace Nabakooza, Marjorie Nakibuule, John Vianney Tushabe, Joel Serubanja, Dorothy Aibo, Hellen Akurut, Josephine Tumusiime, Mateusz Hasso-Agopsowicz, Pontiano Kaleebu, Jonathan Levin, Hazel M. Dockrell, Steven Smith, Emily L. Webb, Alison M. Elliott, Stephen Cose
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
latent Mycobacterium tuberculosis infection
maternal infection
BCG vaccine
cytokine responses
antibody responses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00929/full

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