Association of Obesity with Peripheral Vascular Disease- A Case-control Study
Introduction: Peripheral Vascular Disease (PVD) is an important public health problem, due to its insidious course and the associated co-morbidities. Obesity has been implicated as one of the risk factor besides others. However, the reports on obesity are not consistent. Aim: To assess the assoc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14521/47899_F[SK]_PF1(AKA_KM)_PFA(KM_AKA_SL)_PN(SHU).pdf |
| Summary: | Introduction: Peripheral Vascular Disease (PVD) is an important
public health problem, due to its insidious course and the associated
co-morbidities. Obesity has been implicated as one of the risk factor
besides others. However, the reports on obesity are not consistent.
Aim: To assess the association between central obesity and
PVD along with other risk factors and the present study is
undertaken to examine the correlation of central obesity as a
risk factor for PVD. Further, the association between other risk
factors and PVD was also ascertained.
Materials and Methods: A total of 124 subjects were recruited
in this case-control study. Ankle Brachial Index (ABI) was
measured using peripheral Doppler studies. Patients with ABI
<0.9 were taken as cases and with ABI >0.9 were taken as
controls. Blood pressure was measured in the sitting position
and the authors obtained anthropometric and demographic
data. Chi-square test was used as the test of significance and
p-value <0.05 to be considered as level of significance.
Results: Of the total 124 participants in the study, 62
participants were the cases and 62 participants were controls.
Body Mass Index (BMI) was higher in cases with PVD but Waist
Circumference (WC) and hip circumference were significantly
lower (p-value=0.003 and <0.001 respectively) and Waist-Hip
Ratio (WHR) did not show any significant difference between
cases and controls. Thus, fat mass is located elsewhere in these
individuals, possibly it may be accumulated in the extremities.
Other risk factors like history of smoking, history of alcoholism
and history of diabetes mellitus had a positively significant
association with PVD with p-values <0.001, 0.023 and <0.001
respectively.
Conclusion: The results obtained from this data suggests
that PVD is not associated with central obesity, instead it
provides evidence that PVD correlates with peripheral fat mass.
Subsequent studies separating central and peripheral obesity
are required to get more clarity on the relationship between
obesity and PVD. |
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| ISSN: | 2249-782X 0973-709X |