In vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression

In vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression

Context Toddalolactone, the main component of Toddalia asiatica (L.) Lam. (Rutaceae), has anticancer, antihypertension, anti-inflammatory, and antifungal activities.Objective This study investigated the metabolic characteristics of toddalolactone.Materials and methods Toddalolactone metabolic stabil...

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Bibliographic Details
Main Authors:	Lina Shan, Xianbao Shi, Tingting Hu, Jiayin Hu, Zhe Guo, Yonggui Song, Dan Su, Xiaoyong Zhang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	Pharmaceutical Biology
Subjects:	Liver microsomes species difference enzyme kinetics pharmacokinetics LC-MS/MS
Online Access:	https://www.tandfonline.com/doi/10.1080/13880209.2022.2108062

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