Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of PP-IPs is mediated by IP6 kinases (IP6Ks) and PPIP5 kinases (PPIP5Ks), which transfer phosphate to inositol hexakisphosphate...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/9/2208 |
| _version_ | 1797568459855364096 |
|---|---|
| author | Seulgi Lee Min-Gyu Kim Hyoungjoon Ahn Seyun Kim |
| author_facet | Seulgi Lee Min-Gyu Kim Hyoungjoon Ahn Seyun Kim |
| author_sort | Seulgi Lee |
| collection | DOAJ |
| description | Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of PP-IPs is mediated by IP6 kinases (IP6Ks) and PPIP5 kinases (PPIP5Ks), which transfer phosphate to inositol hexakisphosphate (IP6). Pleiotropic actions of PP-IPs are involved in many key biological processes, including growth, vesicular remodeling, and energy homeostasis. PP-IPs function to regulate their target proteins through allosteric interactions or protein pyrophosphorylation. This review summarizes the current understanding of how PP-IPs control mammalian cellular signaling networks in physiology and disease. |
| first_indexed | 2024-03-10T19:57:17Z |
| format | Article |
| id | doaj.art-3d7176d887d34c6caa48bd60a3c5377d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:57:17Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3d7176d887d34c6caa48bd60a3c5377d2023-11-19T23:50:48ZengMDPI AGMolecules1420-30492020-05-01259220810.3390/molecules25092208Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in MammalsSeulgi Lee0Min-Gyu Kim1Hyoungjoon Ahn2Seyun Kim3Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaInositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of PP-IPs is mediated by IP6 kinases (IP6Ks) and PPIP5 kinases (PPIP5Ks), which transfer phosphate to inositol hexakisphosphate (IP6). Pleiotropic actions of PP-IPs are involved in many key biological processes, including growth, vesicular remodeling, and energy homeostasis. PP-IPs function to regulate their target proteins through allosteric interactions or protein pyrophosphorylation. This review summarizes the current understanding of how PP-IPs control mammalian cellular signaling networks in physiology and disease.https://www.mdpi.com/1420-3049/25/9/2208inositol pyrophosphateIP6KPPIP5Kcell signalingphysiologic functionssignaling molecules |
| spellingShingle | Seulgi Lee Min-Gyu Kim Hyoungjoon Ahn Seyun Kim Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals Molecules inositol pyrophosphate IP6K PPIP5K cell signaling physiologic functions signaling molecules |
| title | Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals |
| title_full | Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals |
| title_fullStr | Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals |
| title_full_unstemmed | Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals |
| title_short | Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals |
| title_sort | inositol pyrophosphates signaling molecules with pleiotropic actions in mammals |
| topic | inositol pyrophosphate IP6K PPIP5K cell signaling physiologic functions signaling molecules |
| url | https://www.mdpi.com/1420-3049/25/9/2208 |
| work_keys_str_mv | AT seulgilee inositolpyrophosphatessignalingmoleculeswithpleiotropicactionsinmammals AT mingyukim inositolpyrophosphatessignalingmoleculeswithpleiotropicactionsinmammals AT hyoungjoonahn inositolpyrophosphatessignalingmoleculeswithpleiotropicactionsinmammals AT seyunkim inositolpyrophosphatessignalingmoleculeswithpleiotropicactionsinmammals |