Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia
We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screen...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2022-11-01
|
| Series: | Bleeding, Thrombosis and Vascular Biology |
| Subjects: | |
| Online Access: | https://btvb.org/btvb/article/view/47 |
| _version_ | 1797835154072272896 |
|---|---|
| author | Anna Poretto Elisabetta Borella Giacomo Turatti Michelangelo Marobin Elena Campello Daniela Tormene Paolo Simioni Luca Spiezia |
| author_facet | Anna Poretto Elisabetta Borella Giacomo Turatti Michelangelo Marobin Elena Campello Daniela Tormene Paolo Simioni Luca Spiezia |
| author_sort | Anna Poretto |
| collection | DOAJ |
| description |
We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.
|
| first_indexed | 2024-04-09T14:48:39Z |
| format | Article |
| id | doaj.art-3d71cc0f117146979f773cb5b9b079c2 |
| institution | Directory Open Access Journal |
| issn | 2785-5309 |
| language | English |
| last_indexed | 2024-04-09T14:48:39Z |
| publishDate | 2022-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Bleeding, Thrombosis and Vascular Biology |
| spelling | doaj.art-3d71cc0f117146979f773cb5b9b079c22023-05-02T10:09:31ZengPAGEPress PublicationsBleeding, Thrombosis and Vascular Biology2785-53092022-11-011310.4081/btvb.2022.47Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophiliaAnna Poretto0Elisabetta Borella1Giacomo Turatti2Michelangelo Marobin3Elena Campello4Daniela Tormene5Paolo Simioni6Luca Spiezia7Thrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, PadovaThrombotic and Hemorrhagic Diseases Unit, Padova University Hospital, Padova We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk. https://btvb.org/btvb/article/view/47recurrent spontaneous abortioninherited thrombophiliablood group |
| spellingShingle | Anna Poretto Elisabetta Borella Giacomo Turatti Michelangelo Marobin Elena Campello Daniela Tormene Paolo Simioni Luca Spiezia Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia Bleeding, Thrombosis and Vascular Biology recurrent spontaneous abortion inherited thrombophilia blood group |
| title | Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| title_full | Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| title_fullStr | Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| title_full_unstemmed | Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| title_short | Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| title_sort | association between non o blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia |
| topic | recurrent spontaneous abortion inherited thrombophilia blood group |
| url | https://btvb.org/btvb/article/view/47 |
| work_keys_str_mv | AT annaporetto associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT elisabettaborella associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT giacomoturatti associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT michelangelomarobin associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT elenacampello associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT danielatormene associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT paolosimioni associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia AT lucaspiezia associationbetweennonobloodtypeandearlyunexplainedrecurrentspontaneousabortioninwomenwithandwithoutinheritedthrombophilia |