Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we conducted a comparative analysis of the structural genes of SARS-CoV-2 and other CoVs. We found that the sequence of the E gene was the most evol...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.801902/full |
| _version_ | 1818366597632360448 |
|---|---|
| author | Qiong Zhang Qiong Zhang Qiong Zhang Huai-Lan Guo Huai-Lan Guo Jing Wang Jing Wang Yao Zhang Yao Zhang Ping-Ji Deng Ping-Ji Deng Fei-Feng Li Fei-Feng Li |
| author_facet | Qiong Zhang Qiong Zhang Qiong Zhang Huai-Lan Guo Huai-Lan Guo Jing Wang Jing Wang Yao Zhang Yao Zhang Ping-Ji Deng Ping-Ji Deng Fei-Feng Li Fei-Feng Li |
| author_sort | Qiong Zhang |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we conducted a comparative analysis of the structural genes of SARS-CoV-2 and other CoVs. We found that the sequence of the E gene was the most evolutionarily conserved across 200 SARS-CoV-2 isolates. The E gene and M gene sequences of SARS-CoV-2 and NC014470 CoV were closely related and fell within the same branch of a phylogenetic tree. The absolute diversity of E gene and M gene sequences of SARS-CoV-2 isolates was similar to that of common CoVs (C-CoVs) infecting other organisms. The absolute diversity of the M gene sequence of the KJ481931 CoV that can infect humans was similar to that of SARS-CoV-2 and C-CoVs infecting other organisms. The M gene sequence of KJ481931 CoV (infecting humans), SARS-CoV-2 and NC014470 CoV (infecting other organisms) were closely related, falling within the same branch of a phylogenetic tree. Patterns of variation and evolutionary characteristics of the N gene and S gene were very similar. These data may be of value for understanding the origins and intermediate hosts of SARS-CoV-2. |
| first_indexed | 2024-12-13T22:38:41Z |
| format | Article |
| id | doaj.art-3d725658a9cc4d56bcdbcd4f0501098a |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-13T22:38:41Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-3d725658a9cc4d56bcdbcd4f0501098a2022-12-21T23:28:55ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.801902801902Structural Genomic Analysis of SARS-CoV-2 and Other CoronavirusesQiong Zhang0Qiong Zhang1Qiong Zhang2Huai-Lan Guo3Huai-Lan Guo4Jing Wang5Jing Wang6Yao Zhang7Yao Zhang8Ping-Ji Deng9Ping-Ji Deng10Fei-Feng Li11Fei-Feng Li12School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, ChinaHubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaSchool of Public Health, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaSchool of Public Health, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaSchool of Public Health, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaSchool of Public Health, Hubei University of Medicine, Shiyan, ChinaHubei Biomedical Detection Sharing Platform in Water Source Area of South to North Water Diversion Project, Hubei University of Medicine, Shiyan, ChinaSchool of Public Health, Hubei University of Medicine, Shiyan, ChinaSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we conducted a comparative analysis of the structural genes of SARS-CoV-2 and other CoVs. We found that the sequence of the E gene was the most evolutionarily conserved across 200 SARS-CoV-2 isolates. The E gene and M gene sequences of SARS-CoV-2 and NC014470 CoV were closely related and fell within the same branch of a phylogenetic tree. The absolute diversity of E gene and M gene sequences of SARS-CoV-2 isolates was similar to that of common CoVs (C-CoVs) infecting other organisms. The absolute diversity of the M gene sequence of the KJ481931 CoV that can infect humans was similar to that of SARS-CoV-2 and C-CoVs infecting other organisms. The M gene sequence of KJ481931 CoV (infecting humans), SARS-CoV-2 and NC014470 CoV (infecting other organisms) were closely related, falling within the same branch of a phylogenetic tree. Patterns of variation and evolutionary characteristics of the N gene and S gene were very similar. These data may be of value for understanding the origins and intermediate hosts of SARS-CoV-2.https://www.frontiersin.org/articles/10.3389/fgene.2022.801902/fullsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)common coronaviruses (C-CoVs)structural geneevolutionintermediate hosts |
| spellingShingle | Qiong Zhang Qiong Zhang Qiong Zhang Huai-Lan Guo Huai-Lan Guo Jing Wang Jing Wang Yao Zhang Yao Zhang Ping-Ji Deng Ping-Ji Deng Fei-Feng Li Fei-Feng Li Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses Frontiers in Genetics severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) common coronaviruses (C-CoVs) structural gene evolution intermediate hosts |
| title | Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses |
| title_full | Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses |
| title_fullStr | Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses |
| title_full_unstemmed | Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses |
| title_short | Structural Genomic Analysis of SARS-CoV-2 and Other Coronaviruses |
| title_sort | structural genomic analysis of sars cov 2 and other coronaviruses |
| topic | severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) common coronaviruses (C-CoVs) structural gene evolution intermediate hosts |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.801902/full |
| work_keys_str_mv | AT qiongzhang structuralgenomicanalysisofsarscov2andothercoronaviruses AT qiongzhang structuralgenomicanalysisofsarscov2andothercoronaviruses AT qiongzhang structuralgenomicanalysisofsarscov2andothercoronaviruses AT huailanguo structuralgenomicanalysisofsarscov2andothercoronaviruses AT huailanguo structuralgenomicanalysisofsarscov2andothercoronaviruses AT jingwang structuralgenomicanalysisofsarscov2andothercoronaviruses AT jingwang structuralgenomicanalysisofsarscov2andothercoronaviruses AT yaozhang structuralgenomicanalysisofsarscov2andothercoronaviruses AT yaozhang structuralgenomicanalysisofsarscov2andothercoronaviruses AT pingjideng structuralgenomicanalysisofsarscov2andothercoronaviruses AT pingjideng structuralgenomicanalysisofsarscov2andothercoronaviruses AT feifengli structuralgenomicanalysisofsarscov2andothercoronaviruses AT feifengli structuralgenomicanalysisofsarscov2andothercoronaviruses |