Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data
The use of radioisotopes in nuclear medicine applications became essential for the diagnosis and follow-up imaging of many oncological, cardiovascular, and neurodegenerative diseases, in a safe and non-invasive way. Their use in the personalized treatment of tumors is on the verge to change the onco...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Physics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2022.1038014/full |
| _version_ | 1798016112080715776 |
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| author | Simona Baruta Simona Baruta Radu Leonte Diana Cocioaba Diana Cocioaba Liviu Craciun Calin Alexandru Ur Dana Niculae |
| author_facet | Simona Baruta Simona Baruta Radu Leonte Diana Cocioaba Diana Cocioaba Liviu Craciun Calin Alexandru Ur Dana Niculae |
| author_sort | Simona Baruta |
| collection | DOAJ |
| description | The use of radioisotopes in nuclear medicine applications became essential for the diagnosis and follow-up imaging of many oncological, cardiovascular, and neurodegenerative diseases, in a safe and non-invasive way. Their use in the personalized treatment of tumors is on the verge to change the oncological patient management. Optimization of the radioisotopes production aims to maximize the production efficiency while minimizing side reactions and costs. A practical approach to balance these non-converging ways is to employ the simulation tools in the process design phase and experimental setup. In this way, the production yield can be estimated and the radionuclide impurities content that appears during the bombardment of the target of interest can be optimally set below acceptable limits. Copper-64 is an emerging radionuclide in nuclear medicine theragnostic applications due to three decay modes, namely electron capture, electron (β−) and positron (β+) emissions, and a 12.7 h half-life, favorable for visualization of fast biological processes. Optimization of 64Cu production by irradiation of enriched 64Ni targets with protons in a particular geometry on a TR-19 cyclotron is discussed in this work. The simulated activity produced on different levels of enrichment of the 64Ni targets was calculated using the Monte Carlo simulation in the Geant4 platform, where a customized solid target irradiation system set-up was replicated; the obtained parameters were implemented in the experiments and the results were compared, aiming to validate the simulation parameters through experimental data.As the simulated and experimental results regarding the production of 64Cu via64Ni(p,n)64Cu reaction are in good compliance, the tool can be further applied for the optimization of the production of other radionuclides on the same set-up. |
| first_indexed | 2024-04-11T15:45:29Z |
| format | Article |
| id | doaj.art-3d72bdde6af34d76a1299307534ac773 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-04-11T15:45:29Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-3d72bdde6af34d76a1299307534ac7732022-12-22T04:15:35ZengFrontiers Media S.A.Frontiers in Physics2296-424X2022-11-011010.3389/fphy.2022.10380141038014Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental dataSimona Baruta0Simona Baruta1Radu Leonte2Diana Cocioaba3Diana Cocioaba4Liviu Craciun5Calin Alexandru Ur6Dana Niculae7Radiopharmaceutical Research Centre, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaExtreme Light Infrastructure—Nuclear Physics, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaRadiopharmaceutical Research Centre, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaRadiopharmaceutical Research Centre, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaUniversity of Bucharest, Doctoral School of Physics, Faculty of Physics, Bucharest, RomaniaRadiopharmaceutical Research Centre, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaExtreme Light Infrastructure—Nuclear Physics, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaRadiopharmaceutical Research Centre, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Magurele, RomaniaThe use of radioisotopes in nuclear medicine applications became essential for the diagnosis and follow-up imaging of many oncological, cardiovascular, and neurodegenerative diseases, in a safe and non-invasive way. Their use in the personalized treatment of tumors is on the verge to change the oncological patient management. Optimization of the radioisotopes production aims to maximize the production efficiency while minimizing side reactions and costs. A practical approach to balance these non-converging ways is to employ the simulation tools in the process design phase and experimental setup. In this way, the production yield can be estimated and the radionuclide impurities content that appears during the bombardment of the target of interest can be optimally set below acceptable limits. Copper-64 is an emerging radionuclide in nuclear medicine theragnostic applications due to three decay modes, namely electron capture, electron (β−) and positron (β+) emissions, and a 12.7 h half-life, favorable for visualization of fast biological processes. Optimization of 64Cu production by irradiation of enriched 64Ni targets with protons in a particular geometry on a TR-19 cyclotron is discussed in this work. The simulated activity produced on different levels of enrichment of the 64Ni targets was calculated using the Monte Carlo simulation in the Geant4 platform, where a customized solid target irradiation system set-up was replicated; the obtained parameters were implemented in the experiments and the results were compared, aiming to validate the simulation parameters through experimental data.As the simulated and experimental results regarding the production of 64Cu via64Ni(p,n)64Cu reaction are in good compliance, the tool can be further applied for the optimization of the production of other radionuclides on the same set-up.https://www.frontiersin.org/articles/10.3389/fphy.2022.1038014/full64Cu productioncyclotron production64Ni targetnuclear reactionsGeant4 simulation |
| spellingShingle | Simona Baruta Simona Baruta Radu Leonte Diana Cocioaba Diana Cocioaba Liviu Craciun Calin Alexandru Ur Dana Niculae Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data Frontiers in Physics 64Cu production cyclotron production 64Ni target nuclear reactions Geant4 simulation |
| title | Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data |
| title_full | Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data |
| title_fullStr | Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data |
| title_full_unstemmed | Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data |
| title_short | Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data |
| title_sort | cyclotron production of 64cu by proton irradiation of enriched 64ni target validation of geant4 simulation parameters through experimental data |
| topic | 64Cu production cyclotron production 64Ni target nuclear reactions Geant4 simulation |
| url | https://www.frontiersin.org/articles/10.3389/fphy.2022.1038014/full |
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