A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2
The objective of this study was to compare the virulence of three different porcine circovirus type 2 (PCV2) genotypes (PCV2a, PCV2b, and PCV2d) in pigs infected with either one of these three PCV2 genotypes versus pigs dually inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2. Pig...
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MDPI AG
2021-08-01
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| author | Taehwan Oh Jeongmin Suh Kee Hwan Park Siyeon Yang Hyejean Cho Chanhee Chae |
| author_facet | Taehwan Oh Jeongmin Suh Kee Hwan Park Siyeon Yang Hyejean Cho Chanhee Chae |
| author_sort | Taehwan Oh |
| collection | DOAJ |
| description | The objective of this study was to compare the virulence of three different porcine circovirus type 2 (PCV2) genotypes (PCV2a, PCV2b, and PCV2d) in pigs infected with either one of these three PCV2 genotypes versus pigs dually inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2. Pigs were inoculated intratracheally with <i>M. hyopneumoniae</i> at 4 weeks of age followed by another intranasal inoculation at 6 weeks of age with one of three PCV2 genotypes. Dual infection with two pathogens produced moderate and severe dyspnea, lethargy, and reduced weight gain in pigs regardless of the PCV2 genotype evaluated compared with pigs only inoculated with PCV2. The overall levels of PCV2d viremia and severity of lymphoid lesions, and PCV2-antigen within lymphoid lesions were significantly higher in pigs dually inoculated with <i>M. hyopneumoniae</i>/PCV2d when compared with all other dually inoculated groups. The level of PCV2 viremia and the production of PCV2-associated lymphoid lesions did not differ significantly among PCV2a, PCV2b, and PCV2d single-inoculated pig groups. The results of this study demonstrated that <i>M. hyopneumoniae</i> potentiated the replication of PCV2d more than it did with the other PCV2 genotypes as measured by lymphoid lesion severity. |
| first_indexed | 2024-03-10T08:30:04Z |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T08:30:04Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-3d75244cda144bf2905b4deb229740aa2023-11-22T09:08:57ZengMDPI AGPathogens2076-08172021-08-0110897910.3390/pathogens10080979A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2Taehwan Oh0Jeongmin Suh1Kee Hwan Park2Siyeon Yang3Hyejean Cho4Chanhee Chae5Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, KoreaThe objective of this study was to compare the virulence of three different porcine circovirus type 2 (PCV2) genotypes (PCV2a, PCV2b, and PCV2d) in pigs infected with either one of these three PCV2 genotypes versus pigs dually inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2. Pigs were inoculated intratracheally with <i>M. hyopneumoniae</i> at 4 weeks of age followed by another intranasal inoculation at 6 weeks of age with one of three PCV2 genotypes. Dual infection with two pathogens produced moderate and severe dyspnea, lethargy, and reduced weight gain in pigs regardless of the PCV2 genotype evaluated compared with pigs only inoculated with PCV2. The overall levels of PCV2d viremia and severity of lymphoid lesions, and PCV2-antigen within lymphoid lesions were significantly higher in pigs dually inoculated with <i>M. hyopneumoniae</i>/PCV2d when compared with all other dually inoculated groups. The level of PCV2 viremia and the production of PCV2-associated lymphoid lesions did not differ significantly among PCV2a, PCV2b, and PCV2d single-inoculated pig groups. The results of this study demonstrated that <i>M. hyopneumoniae</i> potentiated the replication of PCV2d more than it did with the other PCV2 genotypes as measured by lymphoid lesion severity.https://www.mdpi.com/2076-0817/10/8/979<i>Mycoplasma hyopneumoniae</i>porcine circovirus-associated diseaseporcine circovirus type 2PCV2 genotypes |
| spellingShingle | Taehwan Oh Jeongmin Suh Kee Hwan Park Siyeon Yang Hyejean Cho Chanhee Chae A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 Pathogens <i>Mycoplasma hyopneumoniae</i> porcine circovirus-associated disease porcine circovirus type 2 PCV2 genotypes |
| title | A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 |
| title_full | A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 |
| title_fullStr | A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 |
| title_full_unstemmed | A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 |
| title_short | A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with <i>Mycoplasma hyopneumoniae</i> and PCV2 |
| title_sort | comparison of pathogenicity and virulence of three porcine circovirus type 2 pcv2 genotypes a b and d in pigs singularly inoculated with pcv2 and dually inoculated with i mycoplasma hyopneumoniae i and pcv2 |
| topic | <i>Mycoplasma hyopneumoniae</i> porcine circovirus-associated disease porcine circovirus type 2 PCV2 genotypes |
| url | https://www.mdpi.com/2076-0817/10/8/979 |
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