Platelet parameters and the association with morbidity and mortality in Preterm Infants
Background: There is growing recognition of the role of platelets in inflammation and immune responses, and platelets have been associated with various cardiovascular diseases. It is also known that neonatal morbidities are related to overall platelet activity, and platelet parameters may have the p...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187595722200198X |
| _version_ | 1811177272398315520 |
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| author | Po-Yu Hsieh Kai-Hsiang Hsu Ming-Chou Chiang Jen-Fu Hsu Shih-Ming Chu Reyin Lien |
| author_facet | Po-Yu Hsieh Kai-Hsiang Hsu Ming-Chou Chiang Jen-Fu Hsu Shih-Ming Chu Reyin Lien |
| author_sort | Po-Yu Hsieh |
| collection | DOAJ |
| description | Background: There is growing recognition of the role of platelets in inflammation and immune responses, and platelets have been associated with various cardiovascular diseases. It is also known that neonatal morbidities are related to overall platelet activity, and platelet parameters may have the potential to predict morbidities and mortality in preterm infants. This study aimed to assess the initial platelet parameters and the association with major morbidities and mortality in preterm neonates. Methods: We retrospectively reviewed data from very preterm neonates with a gestational age (GA) <32 weeks who were admitted between June 2020 and May 2021 for platelet parameters (counts, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (platelet counts x MPV/10000(%)) at birth. Major morbidities included early- onset sepsis (EOS) ≤3 days after birth, severe intraventricular hemorrhage (IVH) grade ≥3, and early or overall mortality. Results: A total of 197 very preterm neonates were studied. Their mean (±SD) GA was 28.0 ± 2.4 weeks, birth weight was 990 ± 293 g, platelet counts were 245 ± 81 x1000/μL, MPV was 10.0 ± 0.7 fl, PDW was 11.0 ± 1.6 fl, and plateletcrit was 0.24 ± 0.08%. MPV had a weak negative correlation with both GA (r = −0.234, p = 0.001) and BW (r = −0.343, p <0.001). A lower plateletcrit was associated with EOS (0.14 (0.04–0.22) % vs. 0.23 (0.19–0.30) %, p = 0.027), severe IVH ≤7 days after birth (0.18 (0.14–0.27) % vs. 0.23 (0.20–0.30) %, p = 0.022), and early and overall mortality (0.15 (0.20–0.30) % vs. 0.23 (0.20–0.30) %, p = 0.049; 0.20 ± 0.09 % vs. 0.25 ± 0.07 %, p = 0.008). Conclusion: A lower plateletcrit within 24 hours of birth was associated with EOS, severe IVH ≤7 days after birth, and first-week and overall mortality in very preterm neonates. |
| first_indexed | 2024-04-10T22:58:54Z |
| format | Article |
| id | doaj.art-3d7654aad24641028bded0d2f27e3621 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-10T22:58:54Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-3d7654aad24641028bded0d2f27e36212023-01-14T04:26:29ZengElsevierPediatrics and Neonatology1875-95722023-01-016416874Platelet parameters and the association with morbidity and mortality in Preterm InfantsPo-Yu Hsieh0Kai-Hsiang Hsu1Ming-Chou Chiang2Jen-Fu Hsu3Shih-Ming Chu4Reyin Lien5Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan.Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, TaiwanBackground: There is growing recognition of the role of platelets in inflammation and immune responses, and platelets have been associated with various cardiovascular diseases. It is also known that neonatal morbidities are related to overall platelet activity, and platelet parameters may have the potential to predict morbidities and mortality in preterm infants. This study aimed to assess the initial platelet parameters and the association with major morbidities and mortality in preterm neonates. Methods: We retrospectively reviewed data from very preterm neonates with a gestational age (GA) <32 weeks who were admitted between June 2020 and May 2021 for platelet parameters (counts, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (platelet counts x MPV/10000(%)) at birth. Major morbidities included early- onset sepsis (EOS) ≤3 days after birth, severe intraventricular hemorrhage (IVH) grade ≥3, and early or overall mortality. Results: A total of 197 very preterm neonates were studied. Their mean (±SD) GA was 28.0 ± 2.4 weeks, birth weight was 990 ± 293 g, platelet counts were 245 ± 81 x1000/μL, MPV was 10.0 ± 0.7 fl, PDW was 11.0 ± 1.6 fl, and plateletcrit was 0.24 ± 0.08%. MPV had a weak negative correlation with both GA (r = −0.234, p = 0.001) and BW (r = −0.343, p <0.001). A lower plateletcrit was associated with EOS (0.14 (0.04–0.22) % vs. 0.23 (0.19–0.30) %, p = 0.027), severe IVH ≤7 days after birth (0.18 (0.14–0.27) % vs. 0.23 (0.20–0.30) %, p = 0.022), and early and overall mortality (0.15 (0.20–0.30) % vs. 0.23 (0.20–0.30) %, p = 0.049; 0.20 ± 0.09 % vs. 0.25 ± 0.07 %, p = 0.008). Conclusion: A lower plateletcrit within 24 hours of birth was associated with EOS, severe IVH ≤7 days after birth, and first-week and overall mortality in very preterm neonates.http://www.sciencedirect.com/science/article/pii/S187595722200198XMorbidityPlateletPlateletcritPreterm infants |
| spellingShingle | Po-Yu Hsieh Kai-Hsiang Hsu Ming-Chou Chiang Jen-Fu Hsu Shih-Ming Chu Reyin Lien Platelet parameters and the association with morbidity and mortality in Preterm Infants Pediatrics and Neonatology Morbidity Platelet Plateletcrit Preterm infants |
| title | Platelet parameters and the association with morbidity and mortality in Preterm Infants |
| title_full | Platelet parameters and the association with morbidity and mortality in Preterm Infants |
| title_fullStr | Platelet parameters and the association with morbidity and mortality in Preterm Infants |
| title_full_unstemmed | Platelet parameters and the association with morbidity and mortality in Preterm Infants |
| title_short | Platelet parameters and the association with morbidity and mortality in Preterm Infants |
| title_sort | platelet parameters and the association with morbidity and mortality in preterm infants |
| topic | Morbidity Platelet Plateletcrit Preterm infants |
| url | http://www.sciencedirect.com/science/article/pii/S187595722200198X |
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