Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant
Abstract Background The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant. Methods Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin:...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-020-01884-0 |
| _version_ | 1818195915316396032 |
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| author | Peicong Ge Qian Zhang Xun Ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Jizong Zhao |
| author_facet | Peicong Ge Qian Zhang Xun Ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Jizong Zhao |
| author_sort | Peicong Ge |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant. Methods Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching. Results A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296–27.737; P = 0.022). Conclusion Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant. |
| first_indexed | 2024-12-12T01:25:46Z |
| format | Article |
| id | doaj.art-3d767bc23112437cb9f1e17e7ba8582d |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-12T01:25:46Z |
| publishDate | 2020-08-01 |
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| series | BMC Neurology |
| spelling | doaj.art-3d767bc23112437cb9f1e17e7ba8582d2022-12-22T00:43:06ZengBMCBMC Neurology1471-23772020-08-012011610.1186/s12883-020-01884-0Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variantPeicong Ge0Qian Zhang1Xun Ye2Xingju Liu3Xiaofeng Deng4Jia Wang5Rong Wang6Yan Zhang7Dong Zhang8Jizong Zhao9Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant. Methods Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching. Results A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296–27.737; P = 0.022). Conclusion Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant.http://link.springer.com/article/10.1186/s12883-020-01884-0Hemorrhgic sitesCollateral vesselP.R4810 K vaiantMoyamoya diseaseHemorrhage |
| spellingShingle | Peicong Ge Qian Zhang Xun Ye Xingju Liu Xiaofeng Deng Jia Wang Rong Wang Yan Zhang Dong Zhang Jizong Zhao Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant BMC Neurology Hemorrhgic sites Collateral vessel P.R4810 K vaiant Moyamoya disease Hemorrhage |
| title | Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant |
| title_full | Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant |
| title_fullStr | Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant |
| title_full_unstemmed | Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant |
| title_short | Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant |
| title_sort | different subtypes of collateral vessels in hemorrhagic moyamoya disease with p r4810k variant |
| topic | Hemorrhgic sites Collateral vessel P.R4810 K vaiant Moyamoya disease Hemorrhage |
| url | http://link.springer.com/article/10.1186/s12883-020-01884-0 |
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