Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

Natural exosomes can express specific proteins and carbohydrate molecules on the surface and hence have demonstrated the great potentials for gene therapy of cancer. However, the use of natural exosomes is restricted by their low transfection efficiency. Here, we report a novel targeting tLyp-1 exos...

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Bibliographic Details
Main Authors: Jing Bai, Jialun Duan, Rui Liu, Yafei Du, Qian Luo, Yinuo Cui, Zhanbo Su, Jiarui Xu, Ying Xie, Wanliang Lu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Targeting tLyp-1exosomes
Engineering
Transfection
Gene therapy
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619301424

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