Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites?
Understanding the mode of action of membrane contact sites (MCSs) across eukaryotic organisms at the near-atomic level to infer function at the cellular and tissue levels is a challenge scientists are currently facing. These peculiar systems dedicated to inter-organellar communication are perfect ex...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2019.00198/full |
| _version_ | 1818994865057300480 |
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| author | Jules D. Petit Jules D. Petit Françoise Immel Laurence Lins Emmanuelle M. Bayer |
| author_facet | Jules D. Petit Jules D. Petit Françoise Immel Laurence Lins Emmanuelle M. Bayer |
| author_sort | Jules D. Petit |
| collection | DOAJ |
| description | Understanding the mode of action of membrane contact sites (MCSs) across eukaryotic organisms at the near-atomic level to infer function at the cellular and tissue levels is a challenge scientists are currently facing. These peculiar systems dedicated to inter-organellar communication are perfect examples of cellular processes where the interplay between lipids and proteins is critical. In this mini review, we underline the link between membrane lipid environment, the recruitment of proteins at specialized membrane domains and the function of MCSs. More precisely, we want to give insights on the crucial role of lipids in defining the specificity of plant endoplasmic reticulum (ER)-plasma membrane (PM) MCSs and we further propose approaches to study them at multiple scales. Our goal is not so much to go into detailed description of MCSs, as there are numerous focused reviews on the subject, but rather try to pinpoint the critical elements defining those structures and give an original point of view by considering the subject from a near-atomic angle with a focus on lipids. We review current knowledge as to how lipids can define MCS territories, play a role in the recruitment and function of the MCS-associated proteins and in turn, how the lipid environment can be modified by proteins. |
| first_indexed | 2024-12-20T21:04:44Z |
| format | Article |
| id | doaj.art-3d77afc9de7546d39246f047bfbb9b4b |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-20T21:04:44Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-3d77afc9de7546d39246f047bfbb9b4b2022-12-21T19:26:38ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2019-02-011010.3389/fpls.2019.00198442019Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites?Jules D. Petit0Jules D. Petit1Françoise Immel2Laurence Lins3Emmanuelle M. Bayer4UMR5200 CNRS, Laboratory of Membrane Biogenesis, University of Bordeaux, Villenave d’Ornon, FranceLaboratoire de Biophysique Moléculaire aux Interfaces, TERRA Research Centre, GX ABT, Université de Liège, Liège, BelgiumUMR5200 CNRS, Laboratory of Membrane Biogenesis, University of Bordeaux, Villenave d’Ornon, FranceLaboratoire de Biophysique Moléculaire aux Interfaces, TERRA Research Centre, GX ABT, Université de Liège, Liège, BelgiumUMR5200 CNRS, Laboratory of Membrane Biogenesis, University of Bordeaux, Villenave d’Ornon, FranceUnderstanding the mode of action of membrane contact sites (MCSs) across eukaryotic organisms at the near-atomic level to infer function at the cellular and tissue levels is a challenge scientists are currently facing. These peculiar systems dedicated to inter-organellar communication are perfect examples of cellular processes where the interplay between lipids and proteins is critical. In this mini review, we underline the link between membrane lipid environment, the recruitment of proteins at specialized membrane domains and the function of MCSs. More precisely, we want to give insights on the crucial role of lipids in defining the specificity of plant endoplasmic reticulum (ER)-plasma membrane (PM) MCSs and we further propose approaches to study them at multiple scales. Our goal is not so much to go into detailed description of MCSs, as there are numerous focused reviews on the subject, but rather try to pinpoint the critical elements defining those structures and give an original point of view by considering the subject from a near-atomic angle with a focus on lipids. We review current knowledge as to how lipids can define MCS territories, play a role in the recruitment and function of the MCS-associated proteins and in turn, how the lipid environment can be modified by proteins.https://www.frontiersin.org/article/10.3389/fpls.2019.00198/fullmembrane contact sitesplantslipidstether proteinsplasmodesmatabiophysics |
| spellingShingle | Jules D. Petit Jules D. Petit Françoise Immel Laurence Lins Emmanuelle M. Bayer Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? Frontiers in Plant Science membrane contact sites plants lipids tether proteins plasmodesmata biophysics |
| title | Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? |
| title_full | Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? |
| title_fullStr | Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? |
| title_full_unstemmed | Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? |
| title_short | Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites? |
| title_sort | lipids or proteins who is leading the dance at membrane contact sites |
| topic | membrane contact sites plants lipids tether proteins plasmodesmata biophysics |
| url | https://www.frontiersin.org/article/10.3389/fpls.2019.00198/full |
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