Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved]
Background: Cord leptin and cord insulin concentrations may be important biomarkers of child adiposity and cardiovascular health, especially in populations with an increased long-term risk of type 2 diabetes and cardiovascular diseases. We aimed to determine whether cord leptin and insulin are assoc...
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| Format: | Article |
| Language: | English |
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Wellcome
2019-10-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/4-157/v1 |
| _version_ | 1818497587329630208 |
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| author | Jane West Gillian Santorelli Paul Collings Daniel Bingham Peter Whincup Naveed Sattar Tom Norris John Wright Debbie A. Lawlor |
| author_facet | Jane West Gillian Santorelli Paul Collings Daniel Bingham Peter Whincup Naveed Sattar Tom Norris John Wright Debbie A. Lawlor |
| author_sort | Jane West |
| collection | DOAJ |
| description | Background: Cord leptin and cord insulin concentrations may be important biomarkers of child adiposity and cardiovascular health, especially in populations with an increased long-term risk of type 2 diabetes and cardiovascular diseases. We aimed to determine whether cord leptin and insulin are associated with adiposity and early cardiovascular health at age 4/5, and whether any associations differ between White British and Pakistani children. Methods: Using bi-ethnic cohort data from 6060 mother-offspring pairs (2717 (44.8%) White British, 3343 (55.2%) Pakistani), we examined associations of cord leptin and insulin with adiposity (BMI, skinfold thickness) and systolic and diastolic blood pressure at age 4/5. Results: Cord leptin and insulin were higher in Pakistani compared to White British children (7.4 ng/ml versus 6.7 ng/ml and 4.1 mU/L versus 3.63 mU/L, respectively). Associations with adiposity measurements were similar in both groups and close to the null value. For example, each 10 ng/ml higher cord leptin was associated with a difference in mean childhood BMI of 0.10 kg/m2 (95% CI 0.01, 0.19) in White British, 0.01 kg/m2 (95% CI -0.08, 0.10) in Pakistani and 0.04 kg/m2 (95% CI -0.02, 0.11) in both groups combined. Associations with systolic and diastolic blood pressure were also close to the null and consistent in both groups. Conclusions: We found no evidence that cord leptin or insulin were likely to be valuable biomarkers for predicting later adiposity and blood pressure in White British or Pakistani children. For now, other factors such as family history and social-economic status may be more useful markers of risk. |
| first_indexed | 2024-12-10T18:47:21Z |
| format | Article |
| id | doaj.art-3d7cb779ac664b78a87777bd75420bd9 |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-10T18:47:21Z |
| publishDate | 2019-10-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-3d7cb779ac664b78a87777bd75420bd92022-12-22T01:37:26ZengWellcomeWellcome Open Research2398-502X2019-10-01410.12688/wellcomeopenres.15433.116879Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved]Jane West0Gillian Santorelli1Paul Collings2Daniel Bingham3Peter Whincup4Naveed Sattar5Tom Norris6John Wright7Debbie A. Lawlor8Bradford Institute for Health Research, Bradford, BD9 6RJ, UKBradford Institute for Health Research, Bradford, BD9 6RJ, UKBradford Institute for Health Research, Bradford, BD9 6RJ, UKBradford Institute for Health Research, Bradford, BD9 6RJ, UKPopulation Health Research Institute, St George's, University of London, London, SW17 0RE, UKInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UKSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UKBradford Institute for Health Research, Bradford, BD9 6RJ, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UKBackground: Cord leptin and cord insulin concentrations may be important biomarkers of child adiposity and cardiovascular health, especially in populations with an increased long-term risk of type 2 diabetes and cardiovascular diseases. We aimed to determine whether cord leptin and insulin are associated with adiposity and early cardiovascular health at age 4/5, and whether any associations differ between White British and Pakistani children. Methods: Using bi-ethnic cohort data from 6060 mother-offspring pairs (2717 (44.8%) White British, 3343 (55.2%) Pakistani), we examined associations of cord leptin and insulin with adiposity (BMI, skinfold thickness) and systolic and diastolic blood pressure at age 4/5. Results: Cord leptin and insulin were higher in Pakistani compared to White British children (7.4 ng/ml versus 6.7 ng/ml and 4.1 mU/L versus 3.63 mU/L, respectively). Associations with adiposity measurements were similar in both groups and close to the null value. For example, each 10 ng/ml higher cord leptin was associated with a difference in mean childhood BMI of 0.10 kg/m2 (95% CI 0.01, 0.19) in White British, 0.01 kg/m2 (95% CI -0.08, 0.10) in Pakistani and 0.04 kg/m2 (95% CI -0.02, 0.11) in both groups combined. Associations with systolic and diastolic blood pressure were also close to the null and consistent in both groups. Conclusions: We found no evidence that cord leptin or insulin were likely to be valuable biomarkers for predicting later adiposity and blood pressure in White British or Pakistani children. For now, other factors such as family history and social-economic status may be more useful markers of risk.https://wellcomeopenresearch.org/articles/4-157/v1 |
| spellingShingle | Jane West Gillian Santorelli Paul Collings Daniel Bingham Peter Whincup Naveed Sattar Tom Norris John Wright Debbie A. Lawlor Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] Wellcome Open Research |
| title | Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] |
| title_full | Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] |
| title_fullStr | Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] |
| title_full_unstemmed | Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] |
| title_short | Associations of cord leptin and cord insulin with adiposity and blood pressure in White British and Pakistani children aged 4/5 years [version 1; peer review: 2 approved] |
| title_sort | associations of cord leptin and cord insulin with adiposity and blood pressure in white british and pakistani children aged 4 5 years version 1 peer review 2 approved |
| url | https://wellcomeopenresearch.org/articles/4-157/v1 |
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