Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer
Cervical cancer is the second most common cancer in women. The detection of oncopathologies in the early stages of development is a paramount task of modern medicine, which can be solved only by improving modern diagnostic methods. The use of screening for certain tumor markers could complement mode...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-06-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000070 |
| _version_ | 1797868274254348288 |
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| author | Sema Begliarzade Aferin Beilerli Albert Sufianov Rasim Tamrazov Valentin Kudriashov Tatiana Ilyasova Yanchao Liang Ozal Beylerli |
| author_facet | Sema Begliarzade Aferin Beilerli Albert Sufianov Rasim Tamrazov Valentin Kudriashov Tatiana Ilyasova Yanchao Liang Ozal Beylerli |
| author_sort | Sema Begliarzade |
| collection | DOAJ |
| description | Cervical cancer is the second most common cancer in women. The detection of oncopathologies in the early stages of development is a paramount task of modern medicine, which can be solved only by improving modern diagnostic methods. The use of screening for certain tumor markers could complement modern tests such as testing for oncogenic types of human papillomavirus (HPV), cytology, colposcopy with acetic acid and iodine solutions. Such highly informative biomarkers can be long noncoding RNAs (lncRNAs) that are highly specific compared to the mRNA profile and are involved in the regulation of gene expression. LncRNAs are a class of non-coding RNAs molecules that are typically over 200 nucleotides in length. LncRNAs may be involved in the regulation of all major cellular processes, including proliferation and differentiation, metabolism, signaling pathways, and apoptosis. LncRNAs molecules are highly stable due to their small size, which is also their undoubted advantage. The study of individual lncRNAs as regulators of the expression of genes involved in the mechanisms of oncogenesis cervical cancer can be not only of great diagnostic value, but, as a result, of therapeutic significance in cervical cancer patients. This review article will present the characteristics of lncRNAs that allow them to be used as accurate diagnostic and prognostic tools, as well as to consider them as effective therapeutic targets in cervical cancer. |
| first_indexed | 2024-04-09T23:53:20Z |
| format | Article |
| id | doaj.art-3d7e64025bf949ffbc366c3a48ce58b3 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-09T23:53:20Z |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-3d7e64025bf949ffbc366c3a48ce58b32023-03-17T04:33:37ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402023-06-0182233239Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancerSema Begliarzade0Aferin Beilerli1Albert Sufianov2Rasim Tamrazov3Valentin Kudriashov4Tatiana Ilyasova5Yanchao Liang6Ozal Beylerli7Republican Clinical Perinatal Center, Ufa, Republic of Bashkortostan, 450106, RussiaDepartment of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaDepartment of Oncology, Radiology and Radiotherapy, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, RussiaGastric Cancer Center, West China Hospital of Sichuan University, ChinaDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 450008, RussiaDepartment of Neurosurgery, the First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaEducational and Scientific Institute of Neurosurgery, Рeoples’ Friendship University of Russia (RUDN University), Moscow, Russia; Corresponding author. Рeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian.Cervical cancer is the second most common cancer in women. The detection of oncopathologies in the early stages of development is a paramount task of modern medicine, which can be solved only by improving modern diagnostic methods. The use of screening for certain tumor markers could complement modern tests such as testing for oncogenic types of human papillomavirus (HPV), cytology, colposcopy with acetic acid and iodine solutions. Such highly informative biomarkers can be long noncoding RNAs (lncRNAs) that are highly specific compared to the mRNA profile and are involved in the regulation of gene expression. LncRNAs are a class of non-coding RNAs molecules that are typically over 200 nucleotides in length. LncRNAs may be involved in the regulation of all major cellular processes, including proliferation and differentiation, metabolism, signaling pathways, and apoptosis. LncRNAs molecules are highly stable due to their small size, which is also their undoubted advantage. The study of individual lncRNAs as regulators of the expression of genes involved in the mechanisms of oncogenesis cervical cancer can be not only of great diagnostic value, but, as a result, of therapeutic significance in cervical cancer patients. This review article will present the characteristics of lncRNAs that allow them to be used as accurate diagnostic and prognostic tools, as well as to consider them as effective therapeutic targets in cervical cancer.http://www.sciencedirect.com/science/article/pii/S2468054023000070Long non-coding RNAsCervical cancerAbnormal regulationMolecular regulationTherapeutic target |
| spellingShingle | Sema Begliarzade Aferin Beilerli Albert Sufianov Rasim Tamrazov Valentin Kudriashov Tatiana Ilyasova Yanchao Liang Ozal Beylerli Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer Non-coding RNA Research Long non-coding RNAs Cervical cancer Abnormal regulation Molecular regulation Therapeutic target |
| title | Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer |
| title_full | Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer |
| title_fullStr | Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer |
| title_full_unstemmed | Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer |
| title_short | Long non-coding RNAs as promising biomarkers and therapeutic targets in cervical cancer |
| title_sort | long non coding rnas as promising biomarkers and therapeutic targets in cervical cancer |
| topic | Long non-coding RNAs Cervical cancer Abnormal regulation Molecular regulation Therapeutic target |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000070 |
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