C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value
Background: The relationship between pretreatment C-reactive protein to albumin ratio (CAR) and colorectal cancer (CRC) prognosis has been extensively studied in various tumors. However, little is known on CAR and its association with prognosis in CRC. This study aims to investigate the prognostic v...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325819889814 |
| _version_ | 1818503623090372608 |
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| author | Qiang-ping Zhou Xiu-jiang Li |
| author_facet | Qiang-ping Zhou Xiu-jiang Li |
| author_sort | Qiang-ping Zhou |
| collection | DOAJ |
| description | Background: The relationship between pretreatment C-reactive protein to albumin ratio (CAR) and colorectal cancer (CRC) prognosis has been extensively studied in various tumors. However, little is known on CAR and its association with prognosis in CRC. This study aims to investigate the prognostic value of pretreatment CAR in CRC. Methods: We conducted a systematic search of MEDLINE, EMBASE, and Cochrane Library databases for eligible studies evaluating the associations of CAR with survival and/or clinicopathology of CRC. Overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), and clinicopathological features were synthesized and compared. Results: Nine studies including 3431 patients were analyzed in this meta-analysis. Pooled results showed that elevated pretreatment CAR was associated with poor OS (pooled hazards ratio [HR]: 2.18, 95% confidence interval [CI]: 1.70-2.78, P < .001) and DFS/RFS (pooled HR: 2.36, 95% CI: 1.40-3.98, P < .001). Moreover, elevated pretreatment CARs were correlated with male patients, large tumor diameter, late III-IV tumor node metastasis stage tumors, high serum carcinoembryonic antigen and carbohydrate antigen 19-9, and presence of lymphatic invasion and venous invasion. Conclusion: Elevated pretreatment CAR could be an adverse prognostic indicator in patients with CRC. |
| first_indexed | 2024-12-10T21:26:24Z |
| format | Article |
| id | doaj.art-3d7fc8e9655343d6a0a9e1ae56667500 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-10T21:26:24Z |
| publishDate | 2019-11-01 |
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| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-3d7fc8e9655343d6a0a9e1ae566675002022-12-22T01:32:58ZengSAGE PublishingDose-Response1559-32582019-11-011710.1177/1559325819889814C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic ValueQiang-ping Zhou0Xiu-jiang Li1 Department of Emergency Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China Department of Emergency Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaBackground: The relationship between pretreatment C-reactive protein to albumin ratio (CAR) and colorectal cancer (CRC) prognosis has been extensively studied in various tumors. However, little is known on CAR and its association with prognosis in CRC. This study aims to investigate the prognostic value of pretreatment CAR in CRC. Methods: We conducted a systematic search of MEDLINE, EMBASE, and Cochrane Library databases for eligible studies evaluating the associations of CAR with survival and/or clinicopathology of CRC. Overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), and clinicopathological features were synthesized and compared. Results: Nine studies including 3431 patients were analyzed in this meta-analysis. Pooled results showed that elevated pretreatment CAR was associated with poor OS (pooled hazards ratio [HR]: 2.18, 95% confidence interval [CI]: 1.70-2.78, P < .001) and DFS/RFS (pooled HR: 2.36, 95% CI: 1.40-3.98, P < .001). Moreover, elevated pretreatment CARs were correlated with male patients, large tumor diameter, late III-IV tumor node metastasis stage tumors, high serum carcinoembryonic antigen and carbohydrate antigen 19-9, and presence of lymphatic invasion and venous invasion. Conclusion: Elevated pretreatment CAR could be an adverse prognostic indicator in patients with CRC.https://doi.org/10.1177/1559325819889814 |
| spellingShingle | Qiang-ping Zhou Xiu-jiang Li C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value Dose-Response |
| title | C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value |
| title_full | C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value |
| title_fullStr | C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value |
| title_full_unstemmed | C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value |
| title_short | C-Reactive Protein to Albumin Ratio in Colorectal Cancer: A Meta-Analysis of Prognostic Value |
| title_sort | c reactive protein to albumin ratio in colorectal cancer a meta analysis of prognostic value |
| url | https://doi.org/10.1177/1559325819889814 |
| work_keys_str_mv | AT qiangpingzhou creactiveproteintoalbuminratioincolorectalcancerametaanalysisofprognosticvalue AT xiujiangli creactiveproteintoalbuminratioincolorectalcancerametaanalysisofprognosticvalue |