Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is characterized by a variability in clinical manifestations and laboratory abnormalities, which creates objective diagnostic difficulties.Objective: to investigate clinical and laboratory parameters in patients with definite and probable SLE.Patients and methods....
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2020-03-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/989 |
| _version_ | 1826556894584504320 |
|---|---|
| author | V. A. Lila |
| author_facet | V. A. Lila |
| author_sort | V. A. Lila |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is characterized by a variability in clinical manifestations and laboratory abnormalities, which creates objective diagnostic difficulties.Objective: to investigate clinical and laboratory parameters in patients with definite and probable SLE.Patients and methods. The investigation enrolled 94 patients, 38 of whom were diagnosed with probable SLE. All the patients underwent immunological examination and unaffected skin biopsies, followed by an immunohistochemical study, the so-called lupus strip test (LST).Results and discussion. The group of patients with definite SLE showed a direct correlation between positive LST and disease activity (r=0.6), acute skin lesion (r=0.42), and elevated anti-double-stranded DNA antibody concentrations (r=0.37), and their inverse correlation with dry syndrome (r=-0.44). In patients with probable SLE, deposition of immunoreactants in the unaffected skin was detected in almost half of the cases, despite lower disease activity and specific antibody deficiency. Thus, LST that is quite easy to use and interpret its results can be used as an additional criterion for the differential diagnosis of SLE, especially in its early stages. |
| first_indexed | 2024-04-10T02:06:12Z |
| format | Article |
| id | doaj.art-3d806e714a194d43b77e58e5d955c05a |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2025-03-14T08:19:57Z |
| publishDate | 2020-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-3d806e714a194d43b77e58e5d955c05a2025-03-02T13:11:02ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2020-03-01141263110.14412/1996-7012-2020-1-26-312232Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosusV. A. Lila0I.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaSystemic lupus erythematosus (SLE) is characterized by a variability in clinical manifestations and laboratory abnormalities, which creates objective diagnostic difficulties.Objective: to investigate clinical and laboratory parameters in patients with definite and probable SLE.Patients and methods. The investigation enrolled 94 patients, 38 of whom were diagnosed with probable SLE. All the patients underwent immunological examination and unaffected skin biopsies, followed by an immunohistochemical study, the so-called lupus strip test (LST).Results and discussion. The group of patients with definite SLE showed a direct correlation between positive LST and disease activity (r=0.6), acute skin lesion (r=0.42), and elevated anti-double-stranded DNA antibody concentrations (r=0.37), and their inverse correlation with dry syndrome (r=-0.44). In patients with probable SLE, deposition of immunoreactants in the unaffected skin was detected in almost half of the cases, despite lower disease activity and specific antibody deficiency. Thus, LST that is quite easy to use and interpret its results can be used as an additional criterion for the differential diagnosis of SLE, especially in its early stages.https://mrj.ima-press.net/mrj/article/view/989systemic lupus erythematosusprobable systemic lupus erythematosuslupus strip test |
| spellingShingle | V. A. Lila Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus Современная ревматология systemic lupus erythematosus probable systemic lupus erythematosus lupus strip test |
| title | Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| title_full | Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| title_fullStr | Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| title_full_unstemmed | Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| title_short | Clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| title_sort | clinical and laboratory relationships in patients with different variants of the course of systemic lupus erythematosus |
| topic | systemic lupus erythematosus probable systemic lupus erythematosus lupus strip test |
| url | https://mrj.ima-press.net/mrj/article/view/989 |
| work_keys_str_mv | AT valila clinicalandlaboratoryrelationshipsinpatientswithdifferentvariantsofthecourseofsystemiclupuserythematosus |