Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats
Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an immunostimulatory...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09540105.2018.1540552 |
| _version_ | 1818147679663816704 |
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| author | Young Mi Park Hak Yong Lee Yang Gyu Kang Sang Hoon Park Bong Gun Lee Yeon Ju Park Hong Geun Oh Dae In Moon Young Pill Kim Deuk Seon Park Hyang Man Lee Ok jin Kim Hye-Jeong Yang Min Jung Kim Young-Rae Lee |
| author_facet | Young Mi Park Hak Yong Lee Yang Gyu Kang Sang Hoon Park Bong Gun Lee Yeon Ju Park Hong Geun Oh Dae In Moon Young Pill Kim Deuk Seon Park Hyang Man Lee Ok jin Kim Hye-Jeong Yang Min Jung Kim Young-Rae Lee |
| author_sort | Young Mi Park |
| collection | DOAJ |
| description | Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an immunostimulatory effect in vivo and in vitro. Specifically, PPCE significantly enhanced splenocyte proliferation and upregulated inflammatory cytokines (IL-2, IL-12, TNF-α, and IFN-γ) and NK cell activity in vitro. The immunostimulatory effect was further investigated through various immunological assays. Oral administration of PPCE increased the swimming time and number of immune cells in rats. Histological analysis revealed that PPCE administration exerted splenic recovery. Thus, P. oleracea L. based complex extracts may be used as an immunostimulatory agent in medicine or functional foods. |
| first_indexed | 2024-12-11T12:39:05Z |
| format | Article |
| id | doaj.art-3d813e0ff97946c999f975866df19425 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-12-11T12:39:05Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-3d813e0ff97946c999f975866df194252022-12-22T01:07:02ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432019-01-01301132410.1080/09540105.2018.15405521540552Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed ratsYoung Mi Park0Hak Yong Lee1Yang Gyu Kang2Sang Hoon Park3Bong Gun Lee4Yeon Ju Park5Hong Geun Oh6Dae In Moon7Young Pill Kim8Deuk Seon Park9Hyang Man Lee10Ok jin Kim11Hye-Jeong Yang12Min Jung Kim13Young-Rae Lee14INVIVO Co. Ltd.INVIVO Co. Ltd.INVIVO Co. Ltd.Huvet Co. Ltd.Huvet Co. Ltd.Huvet Co. Ltd.Huvet Co. Ltd.Huvet Co. Ltd.Huvet Co. Ltd.MnFkorea, Ltd.MnFkorea, Ltd.Wonkwang UniversityKorea Food Research InstituteKorea Food Research InstituteCollege of Dentistry, Wonkwang UniversityPortulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an immunostimulatory effect in vivo and in vitro. Specifically, PPCE significantly enhanced splenocyte proliferation and upregulated inflammatory cytokines (IL-2, IL-12, TNF-α, and IFN-γ) and NK cell activity in vitro. The immunostimulatory effect was further investigated through various immunological assays. Oral administration of PPCE increased the swimming time and number of immune cells in rats. Histological analysis revealed that PPCE administration exerted splenic recovery. Thus, P. oleracea L. based complex extracts may be used as an immunostimulatory agent in medicine or functional foods.http://dx.doi.org/10.1080/09540105.2018.1540552portulaca oleracea limmunostimulationcytokinespleonocyteimmunosuppressed rats |
| spellingShingle | Young Mi Park Hak Yong Lee Yang Gyu Kang Sang Hoon Park Bong Gun Lee Yeon Ju Park Hong Geun Oh Dae In Moon Young Pill Kim Deuk Seon Park Hyang Man Lee Ok jin Kim Hye-Jeong Yang Min Jung Kim Young-Rae Lee Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats Food and Agricultural Immunology portulaca oleracea l immunostimulation cytokine spleonocyte immunosuppressed rats |
| title | Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats |
| title_full | Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats |
| title_fullStr | Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats |
| title_full_unstemmed | Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats |
| title_short | Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats |
| title_sort | immune enhancing effects of portulaca oleracea l based complex extract in cyclophosphamide induced splenocytes and immunosuppressed rats |
| topic | portulaca oleracea l immunostimulation cytokine spleonocyte immunosuppressed rats |
| url | http://dx.doi.org/10.1080/09540105.2018.1540552 |
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