Classifying the Binding Modes of Disordered Proteins
Disordered proteins often act as interaction hubs in cellular pathways, via the specific recognition of a distinguished set of partners. While disordered regions can adopt a well-defined conformation upon binding, the coupled folding to binding model does not explain how interaction versatility is a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8615 |
| _version_ | 1797547815017119744 |
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| author | Monika Fuxreiter |
| author_facet | Monika Fuxreiter |
| author_sort | Monika Fuxreiter |
| collection | DOAJ |
| description | Disordered proteins often act as interaction hubs in cellular pathways, via the specific recognition of a distinguished set of partners. While disordered regions can adopt a well-defined conformation upon binding, the coupled folding to binding model does not explain how interaction versatility is achieved. Here, I present a classification scheme for the binding modes of disordered protein regions, based on their conformational heterogeneity in the bound state. Binding modes are defined as (i) <b>disorder-to-order transitions</b> leading to a well-defined bound state, (ii) <b>disordered binding</b> leading to a disordered bound state and (iii) <b>fuzzy binding</b> when the degree of disorder in the bound state may vary with the partner or cellular conditions. Fuzzy binding includes polymorphic bound structures, conditional folding and dynamic binding. This classification scheme describes the structural continuum of complexes involving disordered regions as well as their context-dependent interaction behaviors. |
| first_indexed | 2024-03-10T14:49:38Z |
| format | Article |
| id | doaj.art-3d815d3e31db448faf8cbf10af0cf002 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:49:38Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3d815d3e31db448faf8cbf10af0cf0022023-11-20T21:04:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122861510.3390/ijms21228615Classifying the Binding Modes of Disordered ProteinsMonika Fuxreiter0Department of Biomedical Sciences, University of Padova, 35131 Padova, ItalyDisordered proteins often act as interaction hubs in cellular pathways, via the specific recognition of a distinguished set of partners. While disordered regions can adopt a well-defined conformation upon binding, the coupled folding to binding model does not explain how interaction versatility is achieved. Here, I present a classification scheme for the binding modes of disordered protein regions, based on their conformational heterogeneity in the bound state. Binding modes are defined as (i) <b>disorder-to-order transitions</b> leading to a well-defined bound state, (ii) <b>disordered binding</b> leading to a disordered bound state and (iii) <b>fuzzy binding</b> when the degree of disorder in the bound state may vary with the partner or cellular conditions. Fuzzy binding includes polymorphic bound structures, conditional folding and dynamic binding. This classification scheme describes the structural continuum of complexes involving disordered regions as well as their context-dependent interaction behaviors.https://www.mdpi.com/1422-0067/21/22/8615protein interactiondisordered proteinfuzzy bindingcontext-dependenceconformational heterogeneity |
| spellingShingle | Monika Fuxreiter Classifying the Binding Modes of Disordered Proteins International Journal of Molecular Sciences protein interaction disordered protein fuzzy binding context-dependence conformational heterogeneity |
| title | Classifying the Binding Modes of Disordered Proteins |
| title_full | Classifying the Binding Modes of Disordered Proteins |
| title_fullStr | Classifying the Binding Modes of Disordered Proteins |
| title_full_unstemmed | Classifying the Binding Modes of Disordered Proteins |
| title_short | Classifying the Binding Modes of Disordered Proteins |
| title_sort | classifying the binding modes of disordered proteins |
| topic | protein interaction disordered protein fuzzy binding context-dependence conformational heterogeneity |
| url | https://www.mdpi.com/1422-0067/21/22/8615 |
| work_keys_str_mv | AT monikafuxreiter classifyingthebindingmodesofdisorderedproteins |