Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium
Abstract Background Although female sex workers (FSWs) are a well-known high-risk group for Human Papillomavirus (HPV) infections, few tailored intervention programmes for HPV have been established worldwide. The lack of reliable data on the prevalence of HPV and related cervical lesions hampers the...
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| Format: | Article |
| Language: | English |
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BMC
2016-06-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-016-3099-5 |
| _version_ | 1828349598290149376 |
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| author | Alex Vorsters Tine Cornelissen Elke Leuridan Johannes Bogers Davy Vanden Broeck Ina Benoy Herman Goossens Niel Hens Pierre Van Damme |
| author_facet | Alex Vorsters Tine Cornelissen Elke Leuridan Johannes Bogers Davy Vanden Broeck Ina Benoy Herman Goossens Niel Hens Pierre Van Damme |
| author_sort | Alex Vorsters |
| collection | DOAJ |
| description | Abstract Background Although female sex workers (FSWs) are a well-known high-risk group for Human Papillomavirus (HPV) infections, few tailored intervention programmes for HPV have been established worldwide. The lack of reliable data on the prevalence of HPV and related cervical lesions hampers the establishment of evidence-based intervention programmes. The objectives of this study were to describe the prevalence of high-risk Human Papillomavirus (hrHPV) infections and abnormal pap smears in FSWs compared to a control group in Antwerp, Belgium. Methods HPV genotyping and cytology data were analysed from routine Pap smear tests that were collected from both FSWs and the general population (1334 samples for each group) between June 2006 and June 2010. Within the laboratory database, all FSWs were matched 1:1 for age and testing date to determine the ORs of hrHPV genotypes, DNA and cytology outcome. Results The prevalence of hrHPV DNA in FSWs was 41.7 % compared to 19.8 % in the age-matched controls with an overall OR of 2.8 (95 % CI: 2.3–3.4). Significant differences were observed in all age groups, and the most significant differences were observed in the cohort under 21 years of age (prevalence of 64.4 % in FSWs versus 14.8 % in controls; OR 10.3 (95 % CI: 5.0–21.2). Significantly more cervical lesions were observed in FSWs, particularly in the 17- to 21-year old age group (OR for LSIL or HSIL: 10.3 (95 % CI: 3.2–33.8). In both groups, HPV 16 was the most prevalent at 12.1 and 6.6 % in the FSW and control groups, respectively. HPV 18 was the 8th and 7th most frequent genotype at 5.0 and 2.5 % in the FSW and control groups, respectively. Conclusions FSWs have a significantly higher prevalence of hrHPV and more abnormal Pap smears than does the general population in Antwerp, Belgium. The hrHPV prevalence in FSWs is similar to that reported in the literature. The need for tailored intervention programmes should be investigated further. |
| first_indexed | 2024-04-14T01:12:55Z |
| format | Article |
| id | doaj.art-3d84baa3f4e64ecc98390ee0a442d0bd |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-14T01:12:55Z |
| publishDate | 2016-06-01 |
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| series | BMC Public Health |
| spelling | doaj.art-3d84baa3f4e64ecc98390ee0a442d0bd2022-12-22T02:20:58ZengBMCBMC Public Health1471-24582016-06-011611810.1186/s12889-016-3099-5Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, BelgiumAlex Vorsters0Tine Cornelissen1Elke Leuridan2Johannes Bogers3Davy Vanden Broeck4Ina Benoy5Herman Goossens6Niel Hens7Pierre Van Damme8Centre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of AntwerpAntwerp Health House for ProstitutionCentre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of AntwerpAlgemeen Medisch Laboratorium (part of National Reference Centre for HPV)Algemeen Medisch Laboratorium (part of National Reference Centre for HPV)Algemeen Medisch Laboratorium (part of National Reference Centre for HPV)Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpInteruniversity Institute for Biostatistics and Statistical Bioinformatics (I-BIOSTAT), Hasselt UniversityCentre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of AntwerpAbstract Background Although female sex workers (FSWs) are a well-known high-risk group for Human Papillomavirus (HPV) infections, few tailored intervention programmes for HPV have been established worldwide. The lack of reliable data on the prevalence of HPV and related cervical lesions hampers the establishment of evidence-based intervention programmes. The objectives of this study were to describe the prevalence of high-risk Human Papillomavirus (hrHPV) infections and abnormal pap smears in FSWs compared to a control group in Antwerp, Belgium. Methods HPV genotyping and cytology data were analysed from routine Pap smear tests that were collected from both FSWs and the general population (1334 samples for each group) between June 2006 and June 2010. Within the laboratory database, all FSWs were matched 1:1 for age and testing date to determine the ORs of hrHPV genotypes, DNA and cytology outcome. Results The prevalence of hrHPV DNA in FSWs was 41.7 % compared to 19.8 % in the age-matched controls with an overall OR of 2.8 (95 % CI: 2.3–3.4). Significant differences were observed in all age groups, and the most significant differences were observed in the cohort under 21 years of age (prevalence of 64.4 % in FSWs versus 14.8 % in controls; OR 10.3 (95 % CI: 5.0–21.2). Significantly more cervical lesions were observed in FSWs, particularly in the 17- to 21-year old age group (OR for LSIL or HSIL: 10.3 (95 % CI: 3.2–33.8). In both groups, HPV 16 was the most prevalent at 12.1 and 6.6 % in the FSW and control groups, respectively. HPV 18 was the 8th and 7th most frequent genotype at 5.0 and 2.5 % in the FSW and control groups, respectively. Conclusions FSWs have a significantly higher prevalence of hrHPV and more abnormal Pap smears than does the general population in Antwerp, Belgium. The hrHPV prevalence in FSWs is similar to that reported in the literature. The need for tailored intervention programmes should be investigated further.http://link.springer.com/article/10.1186/s12889-016-3099-5Human papilloma virusFemale sex workersEpidemiologyCervical cancerPrevention |
| spellingShingle | Alex Vorsters Tine Cornelissen Elke Leuridan Johannes Bogers Davy Vanden Broeck Ina Benoy Herman Goossens Niel Hens Pierre Van Damme Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium BMC Public Health Human papilloma virus Female sex workers Epidemiology Cervical cancer Prevention |
| title | Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium |
| title_full | Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium |
| title_fullStr | Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium |
| title_full_unstemmed | Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium |
| title_short | Prevalence of high-risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in Antwerp, Belgium |
| title_sort | prevalence of high risk human papillomavirus and abnormal pap smears in female sex workers compared to the general population in antwerp belgium |
| topic | Human papilloma virus Female sex workers Epidemiology Cervical cancer Prevention |
| url | http://link.springer.com/article/10.1186/s12889-016-3099-5 |
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