Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases
Increasing evidence has accumulated that gut microbiome dysbiosis could be linked to neurological diseases, including both neurodegenerative and psychiatric diseases. With the high prevalence of neurological diseases, there is an urgent need to elucidate the underlying mechanisms between the microbi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Medical Technology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmedt.2022.931411/full |
| _version_ | 1797986703074394112 |
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| author | Hohyeon Han Jinah Jang Jinah Jang Jinah Jang Jinah Jang |
| author_facet | Hohyeon Han Jinah Jang Jinah Jang Jinah Jang Jinah Jang |
| author_sort | Hohyeon Han |
| collection | DOAJ |
| description | Increasing evidence has accumulated that gut microbiome dysbiosis could be linked to neurological diseases, including both neurodegenerative and psychiatric diseases. With the high prevalence of neurological diseases, there is an urgent need to elucidate the underlying mechanisms between the microbiome, gut, and brain. However, the standardized animal models for these studies have critical disadvantages for their translation into clinical application, such as limited physiological relevance due to interspecies differences and difficulty interpreting causality from complex systemic interactions. Therefore, alternative in vitro gut–brain axis models are highly required to understand their related pathophysiology and set novel therapeutic strategies. In this review, we outline state-of-the-art biofabrication technologies for modeling in vitro human intestines. Existing 3D gut models are categorized according to their topographical and anatomical similarities to the native gut. In addition, we deliberate future research directions to develop more functional in vitro intestinal models to study the gut–brain axis in neurological diseases rather than simply recreating the morphology. |
| first_indexed | 2024-04-11T07:36:14Z |
| format | Article |
| id | doaj.art-3d8c3e8a126c44dab35915ebda66c34c |
| institution | Directory Open Access Journal |
| issn | 2673-3129 |
| language | English |
| last_indexed | 2024-04-11T07:36:14Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medical Technology |
| spelling | doaj.art-3d8c3e8a126c44dab35915ebda66c34c2022-12-22T04:36:43ZengFrontiers Media S.A.Frontiers in Medical Technology2673-31292022-09-01410.3389/fmedt.2022.931411931411Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseasesHohyeon Han0Jinah Jang1Jinah Jang2Jinah Jang3Jinah Jang4School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, South KoreaSchool of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, South KoreaDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South KoreaDepartment of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South KoreaInstitute of Convergence Science, Yonsei University, Seoul, South KoreaIncreasing evidence has accumulated that gut microbiome dysbiosis could be linked to neurological diseases, including both neurodegenerative and psychiatric diseases. With the high prevalence of neurological diseases, there is an urgent need to elucidate the underlying mechanisms between the microbiome, gut, and brain. However, the standardized animal models for these studies have critical disadvantages for their translation into clinical application, such as limited physiological relevance due to interspecies differences and difficulty interpreting causality from complex systemic interactions. Therefore, alternative in vitro gut–brain axis models are highly required to understand their related pathophysiology and set novel therapeutic strategies. In this review, we outline state-of-the-art biofabrication technologies for modeling in vitro human intestines. Existing 3D gut models are categorized according to their topographical and anatomical similarities to the native gut. In addition, we deliberate future research directions to develop more functional in vitro intestinal models to study the gut–brain axis in neurological diseases rather than simply recreating the morphology.https://www.frontiersin.org/articles/10.3389/fmedt.2022.931411/fullgut-brain axisneurological diseaseenteroendocrine functionbiofabricationin vitro gut models |
| spellingShingle | Hohyeon Han Jinah Jang Jinah Jang Jinah Jang Jinah Jang Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases Frontiers in Medical Technology gut-brain axis neurological disease enteroendocrine function biofabrication in vitro gut models |
| title | Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases |
| title_full | Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases |
| title_fullStr | Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases |
| title_full_unstemmed | Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases |
| title_short | Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases |
| title_sort | recent advances in biofabricated gut models to understand the gut brain axis in neurological diseases |
| topic | gut-brain axis neurological disease enteroendocrine function biofabrication in vitro gut models |
| url | https://www.frontiersin.org/articles/10.3389/fmedt.2022.931411/full |
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